Immunosuppression Reactivates and Disseminates Latent murine Cytomegalovirus

The Division of Infectious Diseases Department of Medicine and Department of Microbiology and Immunology Reed Neurological Research Centre University of California School of Medicine, Los Angeles, California 90024, U.S.A. When searched for by standard virological methods, murine cytomegalovirus (MCM...

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Bibliographic Details
Published in:Journal of general virology 1977-11, Vol.37 (2), p.419-423
Main Authors: Jordan, M. Colin, Shanley, John D, Stevens, Jack G
Format: Article
Language:English
Subjects:
Animals
Antilymphocyte Serum - pharmacology
Cortisone - pharmacology
Cytomegalovirus - growth & development
Cytomegalovirus - immunology
Cytomegalovirus - isolation & purification
Cytomegalovirus Infections - immunology
Cytomegalovirus Infections - microbiology
Disease Models, Animal
Immunosuppression
Mice
Organ Specificity
Salivary Glands - microbiology
Spleen - microbiology
Virus Replication - drug effects
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Summary:The Division of Infectious Diseases Department of Medicine and Department of Microbiology and Immunology Reed Neurological Research Centre University of California School of Medicine, Los Angeles, California 90024, U.S.A. When searched for by standard virological methods, murine cytomegalovirus (MCMV) becomes undetectable by 4 months after inoculation of mice. However, a 2-week regimen of immunosuppression with anti-lymphocyte serum and corticosteroid results in reactivation and dissemination of the virus in virtually all animals. This system should be useful in defining the pathogenesis of generalized cytomegalic disease resulting from reactivation of latent virus in immunocompromised individuals. Received 27 April 1977; accepted 17 June 1977.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-37-2-419