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Immunosuppression Reactivates and Disseminates Latent murine Cytomegalovirus
The Division of Infectious Diseases Department of Medicine and Department of Microbiology and Immunology Reed Neurological Research Centre University of California School of Medicine, Los Angeles, California 90024, U.S.A. When searched for by standard virological methods, murine cytomegalovirus (MCM...
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| Published in: | Journal of general virology 1977-11, Vol.37 (2), p.419-423 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c402t-3ffcbdf0f87af5e44f45e90d2b62c35ad86219c7339347b7c45a6211573d10f03 |
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| container_end_page | 423 |
| container_issue | 2 |
| container_start_page | 419 |
| container_title | Journal of general virology |
| container_volume | 37 |
| creator | Jordan, M. Colin Shanley, John D Stevens, Jack G |
| description | The Division of Infectious Diseases Department of Medicine and Department of Microbiology and Immunology Reed Neurological Research Centre University of California School of Medicine, Los Angeles, California 90024, U.S.A.
When searched for by standard virological methods, murine cytomegalovirus (MCMV) becomes undetectable by 4 months after inoculation of mice. However, a 2-week regimen of immunosuppression with anti-lymphocyte serum and corticosteroid results in reactivation and dissemination of the virus in virtually all animals. This system should be useful in defining the pathogenesis of generalized cytomegalic disease resulting from reactivation of latent virus in immunocompromised individuals.
Received 27 April 1977;
accepted 17 June 1977. |
| doi_str_mv | 10.1099/0022-1317-37-2-419 |
| format | article |
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When searched for by standard virological methods, murine cytomegalovirus (MCMV) becomes undetectable by 4 months after inoculation of mice. However, a 2-week regimen of immunosuppression with anti-lymphocyte serum and corticosteroid results in reactivation and dissemination of the virus in virtually all animals. This system should be useful in defining the pathogenesis of generalized cytomegalic disease resulting from reactivation of latent virus in immunocompromised individuals.
Received 27 April 1977;
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When searched for by standard virological methods, murine cytomegalovirus (MCMV) becomes undetectable by 4 months after inoculation of mice. However, a 2-week regimen of immunosuppression with anti-lymphocyte serum and corticosteroid results in reactivation and dissemination of the virus in virtually all animals. This system should be useful in defining the pathogenesis of generalized cytomegalic disease resulting from reactivation of latent virus in immunocompromised individuals.
Received 27 April 1977;
accepted 17 June 1977.</description><subject>Animals</subject><subject>Antilymphocyte Serum - pharmacology</subject><subject>Cortisone - pharmacology</subject><subject>Cytomegalovirus - growth & development</subject><subject>Cytomegalovirus - immunology</subject><subject>Cytomegalovirus - isolation & purification</subject><subject>Cytomegalovirus Infections - immunology</subject><subject>Cytomegalovirus Infections - microbiology</subject><subject>Disease Models, Animal</subject><subject>Immunosuppression</subject><subject>Mice</subject><subject>Organ Specificity</subject><subject>Salivary Glands - microbiology</subject><subject>Spleen - microbiology</subject><subject>Virus Replication - drug effects</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><recordid>eNo9kFtLwzAUx4N4m9MvID70SZ-iubVZH2XeBgVB9DmkabJFmmYm7WTf3syOvZwD53858APgGqN7jMryASFCIKaYQ8ohgQyXR2CCWZFDkuRjMDkYzsFFjN8IYcZyfgZOCUIcswmoFs4NnY_Deh10jNZ32YeWqrcb2euYya7JnmyM2tnu_1Cl2fWZG4LtdDbf9t7ppWz9xoYhXoITI9uor_Z7Cr5enj_nb7B6f13MHyuoGCI9pMaoujHIzLg0uWbMsFyXqCF1QRTNZTMrCC4Vp7SkjNdcsVymC845bTAyiE7B7di7Dv5n0LEXzkal21Z22g9RcMoZIwVJRjIaVfAxBm3EOlgnw1ZgJHYExQ6Q2AESlAsiEsEUutm3D7XTzSEyIkvy3Siv7HL1a4MWS905mz7U1ovE4VD0B4xken0</recordid><startdate>197711</startdate><enddate>197711</enddate><creator>Jordan, M. Colin</creator><creator>Shanley, John D</creator><creator>Stevens, Jack G</creator><general>Soc General Microbiol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197711</creationdate><title>Immunosuppression Reactivates and Disseminates Latent murine Cytomegalovirus</title><author>Jordan, M. Colin ; Shanley, John D ; Stevens, Jack G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-3ffcbdf0f87af5e44f45e90d2b62c35ad86219c7339347b7c45a6211573d10f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Antilymphocyte Serum - pharmacology</topic><topic>Cortisone - pharmacology</topic><topic>Cytomegalovirus - growth & development</topic><topic>Cytomegalovirus - immunology</topic><topic>Cytomegalovirus - isolation & purification</topic><topic>Cytomegalovirus Infections - immunology</topic><topic>Cytomegalovirus Infections - microbiology</topic><topic>Disease Models, Animal</topic><topic>Immunosuppression</topic><topic>Mice</topic><topic>Organ Specificity</topic><topic>Salivary Glands - microbiology</topic><topic>Spleen - microbiology</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jordan, M. Colin</creatorcontrib><creatorcontrib>Shanley, John D</creatorcontrib><creatorcontrib>Stevens, Jack G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jordan, M. Colin</au><au>Shanley, John D</au><au>Stevens, Jack G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunosuppression Reactivates and Disseminates Latent murine Cytomegalovirus</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>1977-11</date><risdate>1977</risdate><volume>37</volume><issue>2</issue><spage>419</spage><epage>423</epage><pages>419-423</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><abstract>The Division of Infectious Diseases Department of Medicine and Department of Microbiology and Immunology Reed Neurological Research Centre University of California School of Medicine, Los Angeles, California 90024, U.S.A.
When searched for by standard virological methods, murine cytomegalovirus (MCMV) becomes undetectable by 4 months after inoculation of mice. However, a 2-week regimen of immunosuppression with anti-lymphocyte serum and corticosteroid results in reactivation and dissemination of the virus in virtually all animals. This system should be useful in defining the pathogenesis of generalized cytomegalic disease resulting from reactivation of latent virus in immunocompromised individuals.
Received 27 April 1977;
accepted 17 June 1977.</abstract><cop>England</cop><pub>Soc General Microbiol</pub><pmid>200714</pmid><doi>10.1099/0022-1317-37-2-419</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1317 |
| ispartof | Journal of general virology, 1977-11, Vol.37 (2), p.419-423 |
| issn | 0022-1317 1465-2099 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73744262 |
| source | Freely Accessible Journals |
| subjects | Animals Antilymphocyte Serum - pharmacology Cortisone - pharmacology Cytomegalovirus - growth & development Cytomegalovirus - immunology Cytomegalovirus - isolation & purification Cytomegalovirus Infections - immunology Cytomegalovirus Infections - microbiology Disease Models, Animal Immunosuppression Mice Organ Specificity Salivary Glands - microbiology Spleen - microbiology Virus Replication - drug effects |
| title | Immunosuppression Reactivates and Disseminates Latent murine Cytomegalovirus |
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