The reversible behavior of locally invasive endometrial carcinoma in a chromosomally mosaic (45,x/46,xr(x)) young woman treated with clomid

A 22 year‐old phenotypic female with a 45,x/46,x, r(x) mosaic complement had anovulatory cycles, histologically normal ovaries, and atypical endometrial hyperplasia which, when clinically followed by repeated biopsies, was found to progress to locally invasive endometrial carcinoma. This was success...

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Bibliographic Details
Published in:Cancer 1977-12, Vol.40 (6), p.2957-2966
Main Authors: Moukhtar, M., Aleem, F. A., Hung, H. C., Sommers, S. C., Klinger, H. P., Romney, S. L.
Format: Article
Language:English
Subjects:
Adenocarcinoma - drug therapy
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Adult
Chromosome Aberrations
Clomiphene - therapeutic use
Endometrial Hyperplasia - genetics
Endometrial Hyperplasia - pathology
Female
Humans
Mosaicism
Ovulation Induction
Sex Chromosomes
Uterine Neoplasms - drug therapy
Uterine Neoplasms - genetics
Uterine Neoplasms - pathology
X Chromosome
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Summary:A 22 year‐old phenotypic female with a 45,x/46,x, r(x) mosaic complement had anovulatory cycles, histologically normal ovaries, and atypical endometrial hyperplasia which, when clinically followed by repeated biopsies, was found to progress to locally invasive endometrial carcinoma. This was successfully managed by the induction of ovulation with Clomid®, which resulted in conversion of the endometrium to a normal secretory pattern for two subsequent years. Cancer 40:2957‐2966, 1977.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197712)40:6<2957::AID-CNCR2820400631>3.0.CO;2-M