METABOLITES OF GENTAMICIN-PRODUCING MICROMONOSPORA SPECIES: I. ISOLATION AND IDENTIFICATION OF METABOLITES

From the cultural broth of a Micronionospora species 25 aminocyclitol antibiotics were isolated by repeated ion-exchange chromatographic processes. The main components of the metabolites were identified as gentamicin C1, C2, and C1a. The other previously reported gentamicin type antibiotics and some...

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Bibliographic Details
Published in:Journal of antibiotics 1977, Vol.30(11), pp.945-954
Main Authors: BÉRDY, J., PAUNCZ, J. KÁDÁR, VAJNA, ZS. MÉHESFALVI, HORVÁTH, GY, GYIMESI, J., KOCZKA, I.
Format: Article
Language:English
Subjects:
Bacteria - drug effects
Gentamicins - isolation & purification
Gentamicins - pharmacology
Methods
Micromonospora - metabolism
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Summary:From the cultural broth of a Micronionospora species 25 aminocyclitol antibiotics were isolated by repeated ion-exchange chromatographic processes. The main components of the metabolites were identified as gentamicin C1, C2, and C1a. The other previously reported gentamicin type antibiotics and some other degradation products including gentamicin A, B, B1, X2, sisomicin, garamine, gentamines etc. , were identified by chemical, PMR, and mass spectroscopic studies. Besides these, seven new gentamicin type antibiotics were isolated and characterized.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.30.945