Evaluation of 99mTc-HIDA Complex as a Cholescintigraphic Agent

In the reaction labeling N- (2, 6-dimethylphenylcarbamoylmethyl) iminodiacetic acid (HI DA) with 99mTc, several complexes with different chemical characteristics were observed to occur with slight changes in the labeling conditions. Among these complexes, a complex detected in the bile of rats was l...

Full description

Saved in:
Bibliographic Details
Published in:RADIOISOTOPES 1977/10/15, Vol.26(10), pp.702-707
Main Authors: SAJI, Hideo, YOKOYAMA, Akira, ARANO, Yasushi, TANAKA, Hisashi, ODORI, Teruo, MORITA, Rikushi, TORIZUKA, Kanji
Format: Article
Language:Japanese
Subjects:
Acetanilides - analogs & derivatives
Animals
Bile - metabolism
Biliary Tract - diagnostic imaging
Imino Acids
Isotope Labeling
Male
Mice
Penicillamine
Rabbits
Radionuclide Imaging
Rats
Technetium
Time Factors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the reaction labeling N- (2, 6-dimethylphenylcarbamoylmethyl) iminodiacetic acid (HI DA) with 99mTc, several complexes with different chemical characteristics were observed to occur with slight changes in the labeling conditions. Among these complexes, a complex detected in the bile of rats was limited to one complex, named as complex II. The preparation method of 99mTc-HIDA complex II and the exchange reaction between this complex and penicillamine indicate that 99mTc is coordinated with HIDA as low-hydrolyzed 99mTc in this complex. This complex is excreted rapidly through the bile and, within 1 hr, about 65% of the total activity injected is recovered from bile in rats. The organ distribution of this complex was studied in mice by radioassay and in rabbits by scintillation camera and, in both cases, the radioactivity was accumulated in the gallbladder. These results suggest that the 99mTc chemical state, low-hydrolyzed state, relates to the bile excretion behavior of this complex, a potentially useful cholescintigraphic agent.
ISSN:0033-8303
1884-4111
DOI:10.3769/radioisotopes.26.10_702