Effect of libexin combinatum (libexine and emetine) on phagocytosis by polymorphonuclear granulocytes and alveolar macrophages

The ability of human polymorphonuclear granulocytes and alveolar macrophages from rats to ingest Saccharomyces cerevisiae was tested in vitro in the presence of various concentrations of emetine and libexine. Emetine 4.0 and 40.0 microgram/ml caused an increase in the phagocytic index of polymorphon...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1977-12, Vol.12 (5), p.345-348
Main Authors: Balázs, C, Szabó, M, Szerze, P, Leövey, A
Format: Article
Language:English
Subjects:
Adult
Drug Combinations
Emetine - pharmacology
Female
Humans
In Vitro Techniques
Macrophages - drug effects
Male
Middle Aged
Neutrophils - drug effects
Oxadiazoles - pharmacology
Phagocytosis - drug effects
Piperidines - pharmacology
Pulmonary Alveoli - cytology
Saccharomyces cerevisiae
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Summary:The ability of human polymorphonuclear granulocytes and alveolar macrophages from rats to ingest Saccharomyces cerevisiae was tested in vitro in the presence of various concentrations of emetine and libexine. Emetine 4.0 and 40.0 microgram/ml caused an increase in the phagocytic index of polymorphonuclear granulocytes and alveolar macrophages. After oral administration of emetine the phagocytosis-enhancing effect was still apparent. Intracellular killing was not influenced by emetine or libexine.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00562449