Preparation and Antidiabetic Activity of Cyclic Sulfonylthiourea Derivatives

• Published in: Journal of pharmaceutical sciences 1981-08, Vol.70 (8), p.952-956
• Main Authors: Soliman, Raafat, Feid-Allah, Hassan M., Mohamed, Hosny F.
• Format: Article
• Language: English
• Subjects: Animals; antidiabetic activity in mice; Antidiabetic activity-synthesis and evaluation of cyclic sulfonylthiourea derivatives; Antidiabetic activity—synthesis and evaluation of cyclic sulfonylthiourea derivatives, identification by IR spectroscopy; Cyclic sulfonylthiourea derivatives-preparation and evaluation for antidiabetic activity; Cyclic sulfonylthiourea derivatives—preparation and evaluation for antidiabetic activity, IR and PMR spectroscopy; Female; Hydantoins - chemical synthesis; Hypoglycemic Agents - chemical synthesis; identification by IR spectroscopy; IR and PMR spectroscopy; IR spectroscopy-identification of cyclic sulfonylthiourea derivatives; IR spectroscopy—identification of cyclic sulfonylthiourea derivatives, antidiabetic activity in mice; Mice; Pyrazoles - chemical synthesis; Pyrazoles - pharmacology; Thiohydantoins - chemical synthesis; Thiohydantoins - pharmacology; Thiourea - analogs & derivatives; Thiourea - chemical synthesis; Thiourea - pharmacology
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.2600700834

3-Substituted 5-methyl-1-{p-[(3, 5-dimethyl)pyrazol-1-yl]-, 5-methyl-1-{p-[(5-methyl-3-carboxy)pyrazol-1-yl]-, 1-{p-[(3-methyl-5-phenyl)pyrazol-1-yl]-, and 1-{p-[(3-methyl-4-bromo-5-phenyl)pyrazol-1-yl]benzenesulfonyl}-2-thiohydantoin and their 5-methyl-2-thiohydantoin and 5, 6-dihydro-4(3H)-oxo-2(1H)-pyrimidinethione derivatives were prepared for evaluation as hypoglycemic agents. Biological testing showed that some of these compounds possessed antidiabetic activity.