Morphometric analysis of endocrine pancreas in old rats

The hypothesis of a degenerescence of Langerhans islets in senile animals has been tested by the morphometrical analysis of the pancreas of rats 6 and 24 months old. The method has allowed to show the presence in old animals of a higher number of islets per area unit; the distribution curve shows a...

Full description

Saved in:
Bibliographic Details
Published in:Experimental gerontology 1977, Vol.12 (5), p.207-214
Main Authors: Remacle, C., Hauser, N., Jeanjean, M., Gommers, A.
Format: Article
Language:English
Subjects:
Aging
Animals
Cell Nucleus
Connective Tissue - anatomy & histology
Cytoplasm
Islets of Langerhans - anatomy & histology
Islets of Langerhans - cytology
Male
Organ Size
Rats
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The hypothesis of a degenerescence of Langerhans islets in senile animals has been tested by the morphometrical analysis of the pancreas of rats 6 and 24 months old. The method has allowed to show the presence in old animals of a higher number of islets per area unit; the distribution curve shows a shifting towards the larger sizes. If the surrounding connective tissue which thickens with age is not taken into account, the relative volumes occupied by the sinusoid capillaries and the A and B cells appear similar in the two age groups, as well as the nucleo-cytoplasmic ratio of these cells and the granulation of the cells secreting insulin. So, the morphological aspect of Langerhans islets does not reveal a decrease of the insulin stores in the pancreas of old rats.
ISSN:0531-5565
1873-6815
DOI:10.1016/0531-5565(77)90007-9