Morphometric analysis of endocrine pancreas in old rats

The hypothesis of a degenerescence of Langerhans islets in senile animals has been tested by the morphometrical analysis of the pancreas of rats 6 and 24 months old. The method has allowed to show the presence in old animals of a higher number of islets per area unit; the distribution curve shows a...

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Published in:Experimental gerontology 1977, Vol.12 (5), p.207-214
Main Authors: Remacle, C., Hauser, N., Jeanjean, M., Gommers, A.
Format: Article
Language:English
Subjects:
Aging
Animals
Cell Nucleus
Connective Tissue - anatomy & histology
Cytoplasm
Islets of Langerhans - anatomy & histology
Islets of Langerhans - cytology
Male
Organ Size
Rats
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creator Remacle, C.
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Jeanjean, M.
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description The hypothesis of a degenerescence of Langerhans islets in senile animals has been tested by the morphometrical analysis of the pancreas of rats 6 and 24 months old. The method has allowed to show the presence in old animals of a higher number of islets per area unit; the distribution curve shows a shifting towards the larger sizes. If the surrounding connective tissue which thickens with age is not taken into account, the relative volumes occupied by the sinusoid capillaries and the A and B cells appear similar in the two age groups, as well as the nucleo-cytoplasmic ratio of these cells and the granulation of the cells secreting insulin. So, the morphological aspect of Langerhans islets does not reveal a decrease of the insulin stores in the pancreas of old rats.
doi_str_mv 10.1016/0531-5565(77)90007-9
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source Elsevier ScienceDirect Journals
subjects Aging
Animals
Cell Nucleus
Connective Tissue - anatomy & histology
Cytoplasm
Islets of Langerhans - anatomy & histology
Islets of Langerhans - cytology
Male
Organ Size
Rats
title Morphometric analysis of endocrine pancreas in old rats
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