Pharmacology of Sch 11973, N-(2-phenylisopropyl)-N-p-toluene sulfonyl urea, a potential new antianginal agent

• Published in: Japanese journal of pharmacology 1977, Vol.27 (6), p.769-779
• Main Authors: Zitowitz, L, Stimson, J, Wohl, A J, Ehrreich, S J
• Format: Article
• Language: English
• Subjects: Adrenergic beta-Antagonists; Angina Pectoris - drug therapy; Animals; Coronary Disease - drug therapy; Dipyridamole - pharmacology; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Evaluation; Female; Heart Rate - drug effects; Heart Ventricles - drug effects; Male; Nitroglycerin - pharmacology; Propranolol - pharmacology; Sulfonylurea Compounds - administration & dosage; Sulfonylurea Compounds - pharmacology
• ISSN: 0021-5198
• DOI: 10.1254/jjp.27.769

Antianginal drugs were evaluated on the basis of their ability to protect against subepicardial electrogram changes induced by local ventricular ischemia in anesthetized dogs. Sch 11973 [N-(2-phenylisopropyl)-N-p-toluene sulfonyl urea], a potential new antianginal agent, was also effective against local ventricular ischemia with its maximum effect appearing at 1mg/kg, i.v. or i.d. and with a duration of at least 2 hours. Nitroglycerin, at a dose of 0.04 mg/kg given bucally, exerted less protection, lasting on the average less than 15 minutes. Protection by propranolol at 1 mg/kg, i.v., was not better than nitroglycerin, but lasted up to one hour, while dipyridamole was ineffective when given in a dose range of 0.1-10 mg/kg, i.v. Sch 11973 differed from standard antianginal agents which may act via beta-adrenergic blocking activity or alteration of cardiac or circulatory dynamics since no acute pharmacological changes were observed after Sch 11973 was administered.