Central effects of the beta-adrenergic blocking agent acebutolol. A quantitative EEG study using normalised slope descriptors

The effects of acute intravenous injection of acebutolol 25 mg on the EEG were investigated in 5 normal subjects. On-line EEG analysis was carried out by a special purpose mini-computer using normalised slope descriptors (hjorth parameters). No significant changes were found apart from those due to...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1977-12, Vol.12 (5), p.327-331
Main Authors: Kayed, K, Godtlibsen, O B
Format: Article
Language:English
Subjects:
Acebutolol - pharmacology
Computers
Diazepam - pharmacology
Electrocardiography
Electroencephalography
Heart Rate - drug effects
Humans
Male
Time Factors
Online Access:Get full text
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Summary:The effects of acute intravenous injection of acebutolol 25 mg on the EEG were investigated in 5 normal subjects. On-line EEG analysis was carried out by a special purpose mini-computer using normalised slope descriptors (hjorth parameters). No significant changes were found apart from those due to drowsiness in 2 subjects, although minute to minute ECG frequency was significantly lowered (p = 0.031). The EEG, which is considered to be a sensitive tool, failed to show any conclusive evidence of any central action of the drug. The effects of beta-adrenergic blockers on the CNS are not yet fully understood.
ISSN:0031-6970
DOI:10.1007/BF00562446