Dissolution Kinetics of Phenylbutazone

This study investigated the possible effects of simultaneous, noninstantaneous, reversible chemical ionization of carbon acids on the dissolution of a typical pharmaceutical carbon acid, phenylbutazone, and its deutero analog. The dissolution rateversuspH profile for phenylbutazone was consistent wi...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1981-12, Vol.70 (12), p.1358-1365
Main Authors: Mooney, K.G., Rodriguez‐gaxiola, M., Mintun, M., Himmelstein, K.J., Stella, V.J.
Format: Article
Language:English
Subjects:
Anti-inflammatory agents-phenylbutazone
Anti‐inflammatory agents—phenylbutazone, dissolution kinetics
Chemistry, Pharmaceutical
dissolution kinetics
Dissolution-kinetics of phenylbutazone
Hydrogen-Ion Concentration
Kinetics
Kinetics-dissolution phenylbutazone
Naphthalenes
Phenylbutazone
Phenylbutazone-dissolution kinetics
Solubility
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Summary:This study investigated the possible effects of simultaneous, noninstantaneous, reversible chemical ionization of carbon acids on the dissolution of a typical pharmaceutical carbon acid, phenylbutazone, and its deutero analog. The dissolution rateversuspH profile for phenylbutazone was consistent with phenylbutazone acting as if it were an acid where the ionization can be considered instantaneous. In view of the dissolution behavior of phenylbutazone under various conditions, it is unlikely that the noninstantaneous ionization kinetics demonstrated for this compound play a major role in determining the dissolution rate, eitherin vitroorin vivo, since the average residence time in a typical aqueous diffusion layer for phenylbutazone dissolution is longer than the reaction time for its ionization. Slowing the reaction time with a primary isotope effect by deuterium substitution for the ionizable proton caused significant deviation from classical behavior ford‐phenylbutazone.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600701218