Effects of N-[2-(1-Azabicyclo[3, 3, 0]octan-5-yl)ethyl]2-nitroaniline Fumarate (SK-946), a Novel Cognition Activator, on Learning and Memory in Rodent Models

We examined the effects of N-[2-(1-azabicyclo[3, 3, 0] octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946) on cognition in various rodent models. SK-946 slightly suppressed spontaneous motor activity, but had no effect on scopolamine-induced motor facilitation. SK-946 ameliorated scopolamine-, pirenze...

Full description

Saved in:
Bibliographic Details
Published in:Biological & pharmaceutical bulletin 1998/07/15, Vol.21(7), pp.698-703
Main Authors: SUZUKI, Tsunemasa, HIROOKA, Kiyotaka, KANDA, Kazumi, HIROOKA, Hiroko, FURUSAWA, Kenichi
Format: Article
Language:English
Subjects:
active avoidance
Aging - physiology
Aniline Compounds - pharmacology
animal model
Animals
Avoidance Learning
Aziridines - pharmacology
Biological and medical sciences
Bridged Bicyclo Compounds - pharmacology
Choline - analogs & derivatives
Choline - pharmacology
cognition activator
Electric Stimulation
Learning - drug effects
Male
Medical sciences
Memory - drug effects
Memory Disorders
Mice
Mice, Inbred ICR
Morris water maze
Motor Activity - drug effects
Muscarinic Agonists - pharmacology
Neuromuscular Blocking Agents - pharmacology
Neuropharmacology
Neuroprotective agent
Nootropic Agents - pharmacology
passive avoidance
Pharmacology. Drug treatments
Rats
Rats, Inbred F344
Rats, Wistar
Receptors, Muscarinic - drug effects
Rodentia
SK-946
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We examined the effects of N-[2-(1-azabicyclo[3, 3, 0] octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946) on cognition in various rodent models. SK-946 slightly suppressed spontaneous motor activity, but had no effect on scopolamine-induced motor facilitation. SK-946 ameliorated scopolamine-, pirenzepine-, cycloheximide- and electric shock-induced passive avoidance deficits in rodents when administered before acquiring the training. In an active avoidance test, SK-946 accelerated avoidance acquisition in the later half of training without a marked increase in lever-pressing. In more reliable models of cognitive disorders, i.e. an AF64A intracerebroventricular infusion model using the step-through passive avoidance test, an aged rat model using the step-down passive avoidance test and methylazoxymethanol (MAM)-induced microencephalic rat model using the Morris water maze test, SK-946 ameliorated impaired learning and memory. These results suggest an ability of SK-946 to enhance cognitive functions.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.21.698