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Effects of N-[2-(1-Azabicyclo[3, 3, 0]octan-5-yl)ethyl]2-nitroaniline Fumarate (SK-946), a Novel Cognition Activator, on Learning and Memory in Rodent Models
We examined the effects of N-[2-(1-azabicyclo[3, 3, 0] octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946) on cognition in various rodent models. SK-946 slightly suppressed spontaneous motor activity, but had no effect on scopolamine-induced motor facilitation. SK-946 ameliorated scopolamine-, pirenze...
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| Published in: | Biological & pharmaceutical bulletin 1998/07/15, Vol.21(7), pp.698-703 |
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| Main Authors: | , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c567t-78c6793bd0db4893dddf90fc97cdb8e4dc3fce94af8bcf3f978e4f2fda23521d3 |
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| container_end_page | 703 |
| container_issue | 7 |
| container_start_page | 698 |
| container_title | Biological & pharmaceutical bulletin |
| container_volume | 21 |
| creator | SUZUKI, Tsunemasa HIROOKA, Kiyotaka KANDA, Kazumi HIROOKA, Hiroko FURUSAWA, Kenichi |
| description | We examined the effects of N-[2-(1-azabicyclo[3, 3, 0] octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946) on cognition in various rodent models. SK-946 slightly suppressed spontaneous motor activity, but had no effect on scopolamine-induced motor facilitation. SK-946 ameliorated scopolamine-, pirenzepine-, cycloheximide- and electric shock-induced passive avoidance deficits in rodents when administered before acquiring the training. In an active avoidance test, SK-946 accelerated avoidance acquisition in the later half of training without a marked increase in lever-pressing. In more reliable models of cognitive disorders, i.e. an AF64A intracerebroventricular infusion model using the step-through passive avoidance test, an aged rat model using the step-down passive avoidance test and methylazoxymethanol (MAM)-induced microencephalic rat model using the Morris water maze test, SK-946 ameliorated impaired learning and memory. These results suggest an ability of SK-946 to enhance cognitive functions. |
| doi_str_mv | 10.1248/bpb.21.698 |
| format | article |
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SK-946 slightly suppressed spontaneous motor activity, but had no effect on scopolamine-induced motor facilitation. SK-946 ameliorated scopolamine-, pirenzepine-, cycloheximide- and electric shock-induced passive avoidance deficits in rodents when administered before acquiring the training. In an active avoidance test, SK-946 accelerated avoidance acquisition in the later half of training without a marked increase in lever-pressing. In more reliable models of cognitive disorders, i.e. an AF64A intracerebroventricular infusion model using the step-through passive avoidance test, an aged rat model using the step-down passive avoidance test and methylazoxymethanol (MAM)-induced microencephalic rat model using the Morris water maze test, SK-946 ameliorated impaired learning and memory. These results suggest an ability of SK-946 to enhance cognitive functions.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.21.698</identifier><identifier>PMID: 9703252</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>active avoidance ; Aging - physiology ; Aniline Compounds - pharmacology ; animal model ; Animals ; Avoidance Learning ; Aziridines - pharmacology ; Biological and medical sciences ; Bridged Bicyclo Compounds - pharmacology ; Choline - analogs & derivatives ; Choline - pharmacology ; cognition activator ; Electric Stimulation ; Learning - drug effects ; Male ; Medical sciences ; Memory - drug effects ; Memory Disorders ; Mice ; Mice, Inbred ICR ; Morris water maze ; Motor Activity - drug effects ; Muscarinic Agonists - pharmacology ; Neuromuscular Blocking Agents - pharmacology ; Neuropharmacology ; Neuroprotective agent ; Nootropic Agents - pharmacology ; passive avoidance ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred F344 ; Rats, Wistar ; Receptors, Muscarinic - drug effects ; Rodentia ; SK-946</subject><ispartof>Biological and Pharmaceutical Bulletin, 1998/07/15, Vol.21(7), pp.698-703</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1999 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c567t-78c6793bd0db4893dddf90fc97cdb8e4dc3fce94af8bcf3f978e4f2fda23521d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1584334$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9703252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SUZUKI, Tsunemasa</creatorcontrib><creatorcontrib>HIROOKA, Kiyotaka</creatorcontrib><creatorcontrib>KANDA, Kazumi</creatorcontrib><creatorcontrib>HIROOKA, Hiroko</creatorcontrib><creatorcontrib>FURUSAWA, Kenichi</creatorcontrib><title>Effects of N-[2-(1-Azabicyclo[3, 3, 0]octan-5-yl)ethyl]2-nitroaniline Fumarate (SK-946), a Novel Cognition Activator, on Learning and Memory in Rodent Models</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>We examined the effects of N-[2-(1-azabicyclo[3, 3, 0] octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946) on cognition in various rodent models. SK-946 slightly suppressed spontaneous motor activity, but had no effect on scopolamine-induced motor facilitation. SK-946 ameliorated scopolamine-, pirenzepine-, cycloheximide- and electric shock-induced passive avoidance deficits in rodents when administered before acquiring the training. In an active avoidance test, SK-946 accelerated avoidance acquisition in the later half of training without a marked increase in lever-pressing. In more reliable models of cognitive disorders, i.e. an AF64A intracerebroventricular infusion model using the step-through passive avoidance test, an aged rat model using the step-down passive avoidance test and methylazoxymethanol (MAM)-induced microencephalic rat model using the Morris water maze test, SK-946 ameliorated impaired learning and memory. These results suggest an ability of SK-946 to enhance cognitive functions.</description><subject>active avoidance</subject><subject>Aging - physiology</subject><subject>Aniline Compounds - pharmacology</subject><subject>animal model</subject><subject>Animals</subject><subject>Avoidance Learning</subject><subject>Aziridines - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bridged Bicyclo Compounds - pharmacology</subject><subject>Choline - analogs & derivatives</subject><subject>Choline - pharmacology</subject><subject>cognition activator</subject><subject>Electric Stimulation</subject><subject>Learning - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory - drug effects</subject><subject>Memory Disorders</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Morris water maze</subject><subject>Motor Activity - drug effects</subject><subject>Muscarinic Agonists - pharmacology</subject><subject>Neuromuscular Blocking Agents - pharmacology</subject><subject>Neuropharmacology</subject><subject>Neuroprotective agent</subject><subject>Nootropic Agents - pharmacology</subject><subject>passive avoidance</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Rats, Wistar</subject><subject>Receptors, Muscarinic - drug effects</subject><subject>Rodentia</subject><subject>SK-946</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkVuLUzEUhQ-ijHX0xXchoMiMNDWXc5rksZQZFTsjeHkahkNOLp0MaVKTdKD-F_-rKS0VfBFCNjvrY22yV9O8xGiCScvfD-thQvBkKvijZoRpy2BHcPe4GSGBOZzijj9tnuV8jxBiiNCT5kQwRElHRs3vC2uNKhlEC67hDYFnGM5-ycGprfLxho5BPeg2qiID7ODWn5tyt_W3BAZXUpTBeRcMuNysZJLFgLNvn6Fop-djIMF1fDAezOOyoi4GMFPFPcgS0xjUbmFkCi4sgQwaXJlVTFvgAvgatQkFXNXi8_PmiZU-mxeHetr8uLz4Pv8IF18-fJrPFlB1U1Yg42rKBB000kPLBdVaW4GsEkzpgZtWK2qVEa20fFCWWsHqoyVWS0LrpjQ9bd7ufdcp_tyYXPqVy8p4L4OJm9wzyinqOvJfEDPMSUdZBV__A97HTQr1Ez1uW1E5xHGl3u0plWLOydh-nVzd5LbHqN9F29doe4L7Gm2FXx0sN8PK6CN6yLLqbw66zEp6m2RQLv917HhLaVux-R67z0UuzVGXqTjlzW4iFoLuprL9VYcfVXUnU28C_QNgKsGR</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>SUZUKI, Tsunemasa</creator><creator>HIROOKA, Kiyotaka</creator><creator>KANDA, Kazumi</creator><creator>HIROOKA, Hiroko</creator><creator>FURUSAWA, Kenichi</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7QG</scope><scope>7X8</scope></search><sort><creationdate>19980701</creationdate><title>Effects of N-[2-(1-Azabicyclo[3, 3, 0]octan-5-yl)ethyl]2-nitroaniline Fumarate (SK-946), a Novel Cognition Activator, on Learning and Memory in Rodent Models</title><author>SUZUKI, Tsunemasa ; HIROOKA, Kiyotaka ; KANDA, Kazumi ; HIROOKA, Hiroko ; FURUSAWA, Kenichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c567t-78c6793bd0db4893dddf90fc97cdb8e4dc3fce94af8bcf3f978e4f2fda23521d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>active avoidance</topic><topic>Aging - physiology</topic><topic>Aniline Compounds - pharmacology</topic><topic>animal model</topic><topic>Animals</topic><topic>Avoidance Learning</topic><topic>Aziridines - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bridged Bicyclo Compounds - pharmacology</topic><topic>Choline - analogs & derivatives</topic><topic>Choline - pharmacology</topic><topic>cognition activator</topic><topic>Electric Stimulation</topic><topic>Learning - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory - drug effects</topic><topic>Memory Disorders</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Morris water maze</topic><topic>Motor Activity - drug effects</topic><topic>Muscarinic Agonists - pharmacology</topic><topic>Neuromuscular Blocking Agents - pharmacology</topic><topic>Neuropharmacology</topic><topic>Neuroprotective agent</topic><topic>Nootropic Agents - pharmacology</topic><topic>passive avoidance</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Rats, Wistar</topic><topic>Receptors, Muscarinic - drug effects</topic><topic>Rodentia</topic><topic>SK-946</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SUZUKI, Tsunemasa</creatorcontrib><creatorcontrib>HIROOKA, Kiyotaka</creatorcontrib><creatorcontrib>KANDA, Kazumi</creatorcontrib><creatorcontrib>HIROOKA, Hiroko</creatorcontrib><creatorcontrib>FURUSAWA, Kenichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SUZUKI, Tsunemasa</au><au>HIROOKA, Kiyotaka</au><au>KANDA, Kazumi</au><au>HIROOKA, Hiroko</au><au>FURUSAWA, Kenichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of N-[2-(1-Azabicyclo[3, 3, 0]octan-5-yl)ethyl]2-nitroaniline Fumarate (SK-946), a Novel Cognition Activator, on Learning and Memory in Rodent Models</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>21</volume><issue>7</issue><spage>698</spage><epage>703</epage><pages>698-703</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>We examined the effects of N-[2-(1-azabicyclo[3, 3, 0] octan-5-yl)ethyl]2-nitroaniline fumarate (SK-946) on cognition in various rodent models. SK-946 slightly suppressed spontaneous motor activity, but had no effect on scopolamine-induced motor facilitation. SK-946 ameliorated scopolamine-, pirenzepine-, cycloheximide- and electric shock-induced passive avoidance deficits in rodents when administered before acquiring the training. In an active avoidance test, SK-946 accelerated avoidance acquisition in the later half of training without a marked increase in lever-pressing. In more reliable models of cognitive disorders, i.e. an AF64A intracerebroventricular infusion model using the step-through passive avoidance test, an aged rat model using the step-down passive avoidance test and methylazoxymethanol (MAM)-induced microencephalic rat model using the Morris water maze test, SK-946 ameliorated impaired learning and memory. These results suggest an ability of SK-946 to enhance cognitive functions.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>9703252</pmid><doi>10.1248/bpb.21.698</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 1998/07/15, Vol.21(7), pp.698-703 |
| issn | 0918-6158 1347-5215 |
| language | eng |
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| source | Free Full-Text Journals in Chemistry |
| subjects | active avoidance Aging - physiology Aniline Compounds - pharmacology animal model Animals Avoidance Learning Aziridines - pharmacology Biological and medical sciences Bridged Bicyclo Compounds - pharmacology Choline - analogs & derivatives Choline - pharmacology cognition activator Electric Stimulation Learning - drug effects Male Medical sciences Memory - drug effects Memory Disorders Mice Mice, Inbred ICR Morris water maze Motor Activity - drug effects Muscarinic Agonists - pharmacology Neuromuscular Blocking Agents - pharmacology Neuropharmacology Neuroprotective agent Nootropic Agents - pharmacology passive avoidance Pharmacology. Drug treatments Rats Rats, Inbred F344 Rats, Wistar Receptors, Muscarinic - drug effects Rodentia SK-946 |
| title | Effects of N-[2-(1-Azabicyclo[3, 3, 0]octan-5-yl)ethyl]2-nitroaniline Fumarate (SK-946), a Novel Cognition Activator, on Learning and Memory in Rodent Models |
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