Effect of Dehydration on the Pharmacokinetics of Oxytetracycline Hydrochloride Administered Intravenously in Goats ( Capra hircus)

1. The effects of various levels of dehydration induced by water deprivation were studied in six Nubian goats on the pharmacokinetics of oxytetracycline after intravenous administration (5 mg/kg). 2. In goats that had lost an average of 7.6% body weight after 2 days of water deprivation, the elimina...

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Bibliographic Details
Published in:General pharmacology 1998-09, Vol.31 (3), p.455-458
Main Authors: Elsheikh, H.A., Intisar, A.M.Osman, Eltayeb, I.B., Abdullah, A.Salam
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - pharmacokinetics
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Body Water - metabolism
Dehydration
Dehydration - metabolism
goat
Goats
Injections, Intravenous
Male
Medical sciences
Metabolic Clearance Rate - drug effects
oxytetracycline
Oxytetracycline - blood
Oxytetracycline - pharmacokinetics
pharmacokinetics
Pharmacology. Drug treatments
Water Deprivation
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Summary:1. The effects of various levels of dehydration induced by water deprivation were studied in six Nubian goats on the pharmacokinetics of oxytetracycline after intravenous administration (5 mg/kg). 2. In goats that had lost an average of 7.6% body weight after 2 days of water deprivation, the elimination rate constant of the drug was significantly decreased ( P
ISSN:0306-3623
1879-0011
DOI:10.1016/S0306-3623(98)00013-5