Diagnostic accuracy of hepatobiliary scintigraphy with 99mTc-PIPIDA questioned

Majd et al (Pediatrics 67: 140, 1981) refer to hepatobiliary scintigraphy with 99m-labeled p-isopropylacetanilido iminodiacetic acid (99mTc-PIPIDA) as a highly accurate test for differentiating biliary atresia from other causes of neonatal jaundice. We agree that this technique is superior to rose b...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1981-10, Vol.68 (4), p.606-606
Main Authors: Byrne, W J, Euler, A R, Golladay, E S, Seibert, J J
Format: Article
Language:English
Subjects:
Bile Ducts - abnormalities
Humans
Imino Acids
Infant, Newborn
Jaundice, Neonatal - diagnostic imaging
Organotechnetium Compounds
Radionuclide Imaging
Technetium
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Summary:Majd et al (Pediatrics 67: 140, 1981) refer to hepatobiliary scintigraphy with 99m-labeled p-isopropylacetanilido iminodiacetic acid (99mTc-PIPIDA) as a highly accurate test for differentiating biliary atresia from other causes of neonatal jaundice. We agree that this technique is superior to rose bengal. However, their conclusion that it is highly accurate may be premature in view of the limited number of patients. Indeed the test is very sensitive (100%), but prior to their innovative use of phenobarbital it was not very specific (58%).
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.68.4.606