Comparative In Vitro Susceptibility of a Tetracycline-Resistant Chlamydia trachomatis Strain Isolated in Toulouse (France)

Background and Objectives: We recently reported the first isolation of a tetracycline-resistant Chlamydia trachomatis strain in Toulouse from a woman treated with tetracycline. To characterize this isolate, its in vitro susceptibility was compared with those of 34 other C. trachomatis isolates recov...

Full description

Saved in:
Bibliographic Details
Published in:Sexually transmitted diseases 1998-08, Vol.25 (7), p.350-352
Main Authors: LEFEVRE, J.-C, LEPARGNEUR, J.-P
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Chlamydia trachomatis - drug effects
Chlamydia trachomatis - isolation & purification
Female
France
Humans
Male
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Tetracycline Resistance
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and Objectives: We recently reported the first isolation of a tetracycline-resistant Chlamydia trachomatis strain in Toulouse from a woman treated with tetracycline. To characterize this isolate, its in vitro susceptibility was compared with those of 34 other C. trachomatis isolates recovered in Toulouse. Study Design: The susceptibilities of C. trachomatis strains were determined in terms of minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) using McCoy cells in 96-well microdilution plates, with an inoculum of 5.10³ to 1.10⁴ inclusion-forming units/ml. The antimicrobial agents tested were tetracycline, azithromycin, erythromycin, ofloxacin, and pristinamycin. Results: No difference was observed between the MICs and MBCs except for the tetracycline. Tetracycline-resistant strain MIC and MBC were >64 μg/ml, although
ISSN:0148-5717
1537-4521
DOI:10.1097/00007435-199808000-00005