NEW RIFAMYCINS MODIFIED AT POSITIONS 3 AND 4 SYNTHESIS, STRUCTURE AND BIOLOGICAL EVALUATION

A number of semisynthetic rifamycin derivatives modified at positions 3 and/or 4, belonging to general structures 3, 5, and 6 (see Scheme 1), have been prepared. The synthesis, structure and antimicrobial evaluation of the new compounds are described. All the derivatives have "in vitro" an...

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Bibliographic Details
Published in:Journal of antibiotics 1981, Vol.34(8), pp.1033-1038
Main Authors: MARSILI, L., PASQUALUCCI, C. R., VIGEVANI, A., GIOIA, B., SCHIOPPACASSI, G., ORONZO, G.
Format: Article
Language:English
Subjects:
Bacteria - drug effects
Chemical Phenomena
Chemistry
Rifamycins - chemical synthesis
Rifamycins - pharmacology
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Summary:A number of semisynthetic rifamycin derivatives modified at positions 3 and/or 4, belonging to general structures 3, 5, and 6 (see Scheme 1), have been prepared. The synthesis, structure and antimicrobial evaluation of the new compounds are described. All the derivatives have "in vitro" antibacterial activities well comparable with that of rifampicin.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.34.1033