Loading…
Effect of antithrombin III supplementation on inflammatory response in patients with severe sepsis
Antithrombin III (AT III) is an important inhibitor of thrombin activity, as well as of many other proteases of the coagulation system. AT III administration showed beneficial effects on septic multiple organ dysfunction in clinical and experimental studies. It was the aim of this study to determine...
Saved in:
Published in: | Shock (Augusta, Ga.) Ga.), 1998-08, Vol.10 (2), p.90-96 |
---|---|
Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c389t-b1289106d83288726b02d1f4f6ba16862474623863175944b3912b80bd0c16673 |
---|---|
cites | |
container_end_page | 96 |
container_issue | 2 |
container_start_page | 90 |
container_title | Shock (Augusta, Ga.) |
container_volume | 10 |
creator | INTHORN, D HOFFMANN, J. N HARTL, W. H MÜHLBAYER, D JOCHUM, M |
description | Antithrombin III (AT III) is an important inhibitor of thrombin activity, as well as of many other proteases of the coagulation system. AT III administration showed beneficial effects on septic multiple organ dysfunction in clinical and experimental studies. It was the aim of this study to determine whether continuous long-term AT III supplementation alters the systemic inflammatory response in patients with severe sepsis. In a prospective study, 29 surgical patients with severe sepsis were randomly assigned to receive either conventional intensive care treatment (n = 15, control group) or additional AT III supplementation to achieve a plasma AT III activity >120% during a 14 day study period (n = 14, AT III group). Plasma concentrations of interleukin (IL)-6 and IL-8 and of the circulating soluble adhesion molecules sICAM-1 and sE-selectin, as well as of PMN elastase, were determined daily. Additionally, total leukocyte count and C-reactive protein (CRP) were measured daily, and body temperature was registered. Compared to control patients, a down-regulation of plasma IL-6 was observed in the AT III group (p < or = .01). AT III supplementation prevented the continuous increase in sICAM-1 plasma concentration observed in control patients and led to a significant fall in soluble sE-selectin and CRP concentration (p < or = .01). This fall corresponded to a down-regulation of body temperature over time (p < or = .01). There was no AT III effect on IL-8, PMN-elastase concentration, or total leukocyte count. Our results show that long-term AT III supplementation attenuates the systemic inflammatory response in patients with severe sepsis. The down-regulation of IL-6 may also explain the fall in endothelium-derived adhesion molecules and may represent the molecular basis by which AT III exerts its beneficial effects on organ function. |
doi_str_mv | 10.1097/00024382-199808000-00002 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73850586</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73850586</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-b1289106d83288726b02d1f4f6ba16862474623863175944b3912b80bd0c16673</originalsourceid><addsrcrecordid>eNo9kNtKAzEQhoMotVYfQciFeLea0-ZwKaVqoeCNXi_JboIrezKzVfr2pu1aGJjT_8_AhxCm5IESox4JIUxwzTJqjCY6tRnZz87QnOYiNTkV56kmimeMM3aJrgC-DiajZmhmFKNGiTlyqxB8OeI-YNuN9fgZ-9bVHV6v1xi2w9D41nejHeu-wynqLjS2be3Yxx2OHoa-A5-meEiSJAT8m25g8D8--pQGqOEaXQTbgL-Z8gJ9PK_el6_Z5u1lvXzaZCXXZswcZdpQIivNmdaKSUdYRYMI0lkqtWRCCcm4lpyq3AjhuKHMaeIqUlIpFV-g--PdIfbfWw9j0dZQ-qaxne-3UCiuc5In_wLpo7CMPUD0oRhi3dq4Kygp9niLf7zFCW9xwJust9OPrWt9dTJOPNP-btpbKG0Tou3KGk4yxiVXxvA_ML2Bmg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73850586</pqid></control><display><type>article</type><title>Effect of antithrombin III supplementation on inflammatory response in patients with severe sepsis</title><source>Freely Accessible Science Journals</source><creator>INTHORN, D ; HOFFMANN, J. N ; HARTL, W. H ; MÜHLBAYER, D ; JOCHUM, M</creator><creatorcontrib>INTHORN, D ; HOFFMANN, J. N ; HARTL, W. H ; MÜHLBAYER, D ; JOCHUM, M</creatorcontrib><description>Antithrombin III (AT III) is an important inhibitor of thrombin activity, as well as of many other proteases of the coagulation system. AT III administration showed beneficial effects on septic multiple organ dysfunction in clinical and experimental studies. It was the aim of this study to determine whether continuous long-term AT III supplementation alters the systemic inflammatory response in patients with severe sepsis. In a prospective study, 29 surgical patients with severe sepsis were randomly assigned to receive either conventional intensive care treatment (n = 15, control group) or additional AT III supplementation to achieve a plasma AT III activity >120% during a 14 day study period (n = 14, AT III group). Plasma concentrations of interleukin (IL)-6 and IL-8 and of the circulating soluble adhesion molecules sICAM-1 and sE-selectin, as well as of PMN elastase, were determined daily. Additionally, total leukocyte count and C-reactive protein (CRP) were measured daily, and body temperature was registered. Compared to control patients, a down-regulation of plasma IL-6 was observed in the AT III group (p < or = .01). AT III supplementation prevented the continuous increase in sICAM-1 plasma concentration observed in control patients and led to a significant fall in soluble sE-selectin and CRP concentration (p < or = .01). This fall corresponded to a down-regulation of body temperature over time (p < or = .01). There was no AT III effect on IL-8, PMN-elastase concentration, or total leukocyte count. Our results show that long-term AT III supplementation attenuates the systemic inflammatory response in patients with severe sepsis. The down-regulation of IL-6 may also explain the fall in endothelium-derived adhesion molecules and may represent the molecular basis by which AT III exerts its beneficial effects on organ function.</description><identifier>ISSN: 1073-2322</identifier><identifier>EISSN: 1540-0514</identifier><identifier>DOI: 10.1097/00024382-199808000-00002</identifier><identifier>PMID: 9721974</identifier><language>eng</language><publisher>Augusta, GA: BioMedical Press</publisher><subject>Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anticoagulants - therapeutic use ; Antithrombin III - therapeutic use ; Biological and medical sciences ; C-Reactive Protein - analysis ; Critical Care ; E-Selectin - blood ; Emergency and intensive care: infection, septic shock ; Female ; Humans ; Inflammation ; Intensive care medicine ; Intercellular Adhesion Molecule-1 - blood ; Interleukin-6 - blood ; Interleukin-8 - blood ; Leukocyte Count ; Male ; Medical sciences ; Middle Aged ; Multiple Organ Failure - blood ; Multiple Organ Failure - immunology ; Multiple Organ Failure - therapy ; Prospective Studies ; Sepsis - blood ; Sepsis - immunology ; Sepsis - therapy</subject><ispartof>Shock (Augusta, Ga.), 1998-08, Vol.10 (2), p.90-96</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-b1289106d83288726b02d1f4f6ba16862474623863175944b3912b80bd0c16673</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2363799$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9721974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>INTHORN, D</creatorcontrib><creatorcontrib>HOFFMANN, J. N</creatorcontrib><creatorcontrib>HARTL, W. H</creatorcontrib><creatorcontrib>MÜHLBAYER, D</creatorcontrib><creatorcontrib>JOCHUM, M</creatorcontrib><title>Effect of antithrombin III supplementation on inflammatory response in patients with severe sepsis</title><title>Shock (Augusta, Ga.)</title><addtitle>Shock</addtitle><description>Antithrombin III (AT III) is an important inhibitor of thrombin activity, as well as of many other proteases of the coagulation system. AT III administration showed beneficial effects on septic multiple organ dysfunction in clinical and experimental studies. It was the aim of this study to determine whether continuous long-term AT III supplementation alters the systemic inflammatory response in patients with severe sepsis. In a prospective study, 29 surgical patients with severe sepsis were randomly assigned to receive either conventional intensive care treatment (n = 15, control group) or additional AT III supplementation to achieve a plasma AT III activity >120% during a 14 day study period (n = 14, AT III group). Plasma concentrations of interleukin (IL)-6 and IL-8 and of the circulating soluble adhesion molecules sICAM-1 and sE-selectin, as well as of PMN elastase, were determined daily. Additionally, total leukocyte count and C-reactive protein (CRP) were measured daily, and body temperature was registered. Compared to control patients, a down-regulation of plasma IL-6 was observed in the AT III group (p < or = .01). AT III supplementation prevented the continuous increase in sICAM-1 plasma concentration observed in control patients and led to a significant fall in soluble sE-selectin and CRP concentration (p < or = .01). This fall corresponded to a down-regulation of body temperature over time (p < or = .01). There was no AT III effect on IL-8, PMN-elastase concentration, or total leukocyte count. Our results show that long-term AT III supplementation attenuates the systemic inflammatory response in patients with severe sepsis. The down-regulation of IL-6 may also explain the fall in endothelium-derived adhesion molecules and may represent the molecular basis by which AT III exerts its beneficial effects on organ function.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anticoagulants - therapeutic use</subject><subject>Antithrombin III - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>C-Reactive Protein - analysis</subject><subject>Critical Care</subject><subject>E-Selectin - blood</subject><subject>Emergency and intensive care: infection, septic shock</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Intensive care medicine</subject><subject>Intercellular Adhesion Molecule-1 - blood</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-8 - blood</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple Organ Failure - blood</subject><subject>Multiple Organ Failure - immunology</subject><subject>Multiple Organ Failure - therapy</subject><subject>Prospective Studies</subject><subject>Sepsis - blood</subject><subject>Sepsis - immunology</subject><subject>Sepsis - therapy</subject><issn>1073-2322</issn><issn>1540-0514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNo9kNtKAzEQhoMotVYfQciFeLea0-ZwKaVqoeCNXi_JboIrezKzVfr2pu1aGJjT_8_AhxCm5IESox4JIUxwzTJqjCY6tRnZz87QnOYiNTkV56kmimeMM3aJrgC-DiajZmhmFKNGiTlyqxB8OeI-YNuN9fgZ-9bVHV6v1xi2w9D41nejHeu-wynqLjS2be3Yxx2OHoa-A5-meEiSJAT8m25g8D8--pQGqOEaXQTbgL-Z8gJ9PK_el6_Z5u1lvXzaZCXXZswcZdpQIivNmdaKSUdYRYMI0lkqtWRCCcm4lpyq3AjhuKHMaeIqUlIpFV-g--PdIfbfWw9j0dZQ-qaxne-3UCiuc5In_wLpo7CMPUD0oRhi3dq4Kygp9niLf7zFCW9xwJust9OPrWt9dTJOPNP-btpbKG0Tou3KGk4yxiVXxvA_ML2Bmg</recordid><startdate>19980801</startdate><enddate>19980801</enddate><creator>INTHORN, D</creator><creator>HOFFMANN, J. N</creator><creator>HARTL, W. H</creator><creator>MÜHLBAYER, D</creator><creator>JOCHUM, M</creator><general>BioMedical Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980801</creationdate><title>Effect of antithrombin III supplementation on inflammatory response in patients with severe sepsis</title><author>INTHORN, D ; HOFFMANN, J. N ; HARTL, W. H ; MÜHLBAYER, D ; JOCHUM, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-b1289106d83288726b02d1f4f6ba16862474623863175944b3912b80bd0c16673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anticoagulants - therapeutic use</topic><topic>Antithrombin III - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>C-Reactive Protein - analysis</topic><topic>Critical Care</topic><topic>E-Selectin - blood</topic><topic>Emergency and intensive care: infection, septic shock</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Intensive care medicine</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-8 - blood</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple Organ Failure - blood</topic><topic>Multiple Organ Failure - immunology</topic><topic>Multiple Organ Failure - therapy</topic><topic>Prospective Studies</topic><topic>Sepsis - blood</topic><topic>Sepsis - immunology</topic><topic>Sepsis - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>INTHORN, D</creatorcontrib><creatorcontrib>HOFFMANN, J. N</creatorcontrib><creatorcontrib>HARTL, W. H</creatorcontrib><creatorcontrib>MÜHLBAYER, D</creatorcontrib><creatorcontrib>JOCHUM, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Shock (Augusta, Ga.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>INTHORN, D</au><au>HOFFMANN, J. N</au><au>HARTL, W. H</au><au>MÜHLBAYER, D</au><au>JOCHUM, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of antithrombin III supplementation on inflammatory response in patients with severe sepsis</atitle><jtitle>Shock (Augusta, Ga.)</jtitle><addtitle>Shock</addtitle><date>1998-08-01</date><risdate>1998</risdate><volume>10</volume><issue>2</issue><spage>90</spage><epage>96</epage><pages>90-96</pages><issn>1073-2322</issn><eissn>1540-0514</eissn><abstract>Antithrombin III (AT III) is an important inhibitor of thrombin activity, as well as of many other proteases of the coagulation system. AT III administration showed beneficial effects on septic multiple organ dysfunction in clinical and experimental studies. It was the aim of this study to determine whether continuous long-term AT III supplementation alters the systemic inflammatory response in patients with severe sepsis. In a prospective study, 29 surgical patients with severe sepsis were randomly assigned to receive either conventional intensive care treatment (n = 15, control group) or additional AT III supplementation to achieve a plasma AT III activity >120% during a 14 day study period (n = 14, AT III group). Plasma concentrations of interleukin (IL)-6 and IL-8 and of the circulating soluble adhesion molecules sICAM-1 and sE-selectin, as well as of PMN elastase, were determined daily. Additionally, total leukocyte count and C-reactive protein (CRP) were measured daily, and body temperature was registered. Compared to control patients, a down-regulation of plasma IL-6 was observed in the AT III group (p < or = .01). AT III supplementation prevented the continuous increase in sICAM-1 plasma concentration observed in control patients and led to a significant fall in soluble sE-selectin and CRP concentration (p < or = .01). This fall corresponded to a down-regulation of body temperature over time (p < or = .01). There was no AT III effect on IL-8, PMN-elastase concentration, or total leukocyte count. Our results show that long-term AT III supplementation attenuates the systemic inflammatory response in patients with severe sepsis. The down-regulation of IL-6 may also explain the fall in endothelium-derived adhesion molecules and may represent the molecular basis by which AT III exerts its beneficial effects on organ function.</abstract><cop>Augusta, GA</cop><pub>BioMedical Press</pub><pmid>9721974</pmid><doi>10.1097/00024382-199808000-00002</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1073-2322 |
ispartof | Shock (Augusta, Ga.), 1998-08, Vol.10 (2), p.90-96 |
issn | 1073-2322 1540-0514 |
language | eng |
recordid | cdi_proquest_miscellaneous_73850586 |
source | Freely Accessible Science Journals |
subjects | Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anticoagulants - therapeutic use Antithrombin III - therapeutic use Biological and medical sciences C-Reactive Protein - analysis Critical Care E-Selectin - blood Emergency and intensive care: infection, septic shock Female Humans Inflammation Intensive care medicine Intercellular Adhesion Molecule-1 - blood Interleukin-6 - blood Interleukin-8 - blood Leukocyte Count Male Medical sciences Middle Aged Multiple Organ Failure - blood Multiple Organ Failure - immunology Multiple Organ Failure - therapy Prospective Studies Sepsis - blood Sepsis - immunology Sepsis - therapy |
title | Effect of antithrombin III supplementation on inflammatory response in patients with severe sepsis |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T17%3A57%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20antithrombin%20III%20supplementation%20on%20inflammatory%20response%20in%20patients%20with%20severe%20sepsis&rft.jtitle=Shock%20(Augusta,%20Ga.)&rft.au=INTHORN,%20D&rft.date=1998-08-01&rft.volume=10&rft.issue=2&rft.spage=90&rft.epage=96&rft.pages=90-96&rft.issn=1073-2322&rft.eissn=1540-0514&rft_id=info:doi/10.1097/00024382-199808000-00002&rft_dat=%3Cproquest_cross%3E73850586%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c389t-b1289106d83288726b02d1f4f6ba16862474623863175944b3912b80bd0c16673%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=73850586&rft_id=info:pmid/9721974&rfr_iscdi=true |