The extracellular matrix in balloon arterial injury: A novel target for restenosis prevention

The role of the extracellular matrix (ECM) in the pathobiology of restenosis has not been fully appreciated. Recent discoveries have shown the ECM to be a complex, heterogeneous structure whose components are dynamically altered in response to vascular injury. This report reviews the structure and f...

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Bibliographic Details
Published in:Progress in cardiovascular diseases 1998-07, Vol.41 (1), p.35-49
Main Authors: Batchelor, Wayne B., Robinson, Ranga, Strauss, Bradley H.
Format: Article
Language:English
Subjects:
Angioplasty, Balloon - adverse effects
Animals
Biological and medical sciences
Coronary Disease - etiology
Coronary Disease - physiopathology
Coronary Disease - prevention & control
Coronary Vessels - injuries
Coronary Vessels - physiopathology
Diseases of the cardiovascular system
Extracellular Matrix - physiology
Extracellular Matrix Proteins - metabolism
Humans
Medical sciences
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Secondary Prevention
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Summary:The role of the extracellular matrix (ECM) in the pathobiology of restenosis has not been fully appreciated. Recent discoveries have shown the ECM to be a complex, heterogeneous structure whose components are dynamically altered in response to vascular injury. This report reviews the structure and function of vascular ECM and the importance of the matrix in modulating the vascular response to arterial injury such as balloon angioplasty and atherosclerosis.
ISSN:0033-0620
1532-8643
DOI:10.1016/S0033-0620(98)80021-2