DEFLECTINS, NEW ANTIMICROBIAL AZAPHILONES FROM ASPERGILLUS DEFLECTUS

Five structurally related, angular azaphilones, the deflectins, were isolated from the mycelia of Aspergillus deflectus. The structures of all compounds have been established. Besides the inhibitory effects on the growth of bacteria and fungi, these compounds showed lytic activity towards bacteria a...

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Bibliographic Details
Published in:Journal of antibiotics 1981, Vol.34(8), pp.923-928
Main Authors: ANKE, H., KEMMER, T., HÖFLE, G.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Aspergillus - analysis
Benzopyrans - isolation & purification
Benzopyrans - pharmacology
Chemical Phenomena
Chemistry
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Summary:Five structurally related, angular azaphilones, the deflectins, were isolated from the mycelia of Aspergillus deflectus. The structures of all compounds have been established. Besides the inhibitory effects on the growth of bacteria and fungi, these compounds showed lytic activity towards bacteria and erythrocytes and cytotoxic activity towards cells of the ascitic form of Ehrlich carcinoma of mice. The inhibitory effects of the deflectins could be reversed by the addition of serum or serum albumin.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.34.923