The DF-1 Chicken Fibroblast Cell Line: Transformation Induced by Diverse Oncogenes and Cell Death Resulting from Infection by Avian Leukosis Viruses

DF-1 is a continuous cell line of chicken embryo fibroblasts. The cells are free of endogenous sequences related to avian sarcoma and leukosis viruses and have normal fibroblastic morphology. DF-1 cells support the replication of avian retroviruses; diverse oncogenes induce foci of oncogenic transfo...

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Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 1998-09, Vol.248 (2), p.295-304
Main Authors: Himly, Martin, Foster, Douglas N., Bottoli, Ivan, Iacovoni, Jason S., Vogt, Peter K.
Format: Article
Language:English
Subjects:
Animals
Avian leukosis virus
Avian Leukosis Virus - physiology
Cell Death
Cell Line - physiology
Cell Line - virology
Cell Transformation, Neoplastic
Cells, Cultured
Chick Embryo
Chickens
Fibroblasts - physiology
Fibroblasts - virology
Genes, jun - physiology
Oncogenes - physiology
Virus Replication
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Description
Summary:DF-1 is a continuous cell line of chicken embryo fibroblasts. The cells are free of endogenous sequences related to avian sarcoma and leukosis viruses and have normal fibroblastic morphology. DF-1 cells support the replication of avian retroviruses; diverse oncogenes induce foci of oncogenic transformation on monolayers of DF-1, and avian leukosis viruses of envelope subgroups B, D, and C induce cell death and form plaques. The new cell line will greatly facilitate studies on oncogenic transformation and cell killing by avian viruses.
ISSN:0042-6822
1096-0341
DOI:10.1006/viro.1998.9290