Maternal age-specific risk of Down syndrome in an Asian population: a report of the Taiwan Down syndrome screening group

This study is a novel approach in establishing the maternal age‐specific risk for Down syndrome screening in an Asian population. The relative frequency by one‐year maternal age interval in women who had live births in the Taiwan area between 1975 and 1995 was used as the age‐specific distribution o...

Full description

Saved in:
Bibliographic Details
Published in:Prenatal diagnosis 1998-07, Vol.18 (7), p.675-682
Main Authors: Sheu, Bor-Ching, Shyu, Ming-Kwang, Lee, Chien-Nan, Kuo, Bo-Jein, Tseng, Yun-Ying, Hsieh, Fon-Jou
Format: Article
Language:English
Subjects:
Adolescent
Adult
Asian risk
Biological and medical sciences
Down syndrome
Down Syndrome - epidemiology
Female
Gynecology. Andrology. Obstetrics
Humans
Management. Prenatal diagnosis
Maternal Age
Medical sciences
Middle Aged
Pregnancy
Pregnancy. Fetus. Placenta
Registries
Risk Factors
Taiwan - epidemiology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study is a novel approach in establishing the maternal age‐specific risk for Down syndrome screening in an Asian population. The relative frequency by one‐year maternal age interval in women who had live births in the Taiwan area between 1975 and 1995 was used as the age‐specific distribution of women who had unaffected pregnancies. Data about Down syndrome live births were obtained from the Taiwan Down Syndrome Association to establish the age distribution of women who had Down syndrome live births. The relative frequencies and the likelihood ratio by one‐year maternal age interval was calculated and smoothed by running median and moving average smoothing methods. The age‐specific risk was established by multiplying the total population risk by the likelihood ratio of the specific maternal age. The total live births in the Taiwan area between 1975 and 1995 were 7 232 689. A total of 527 cases of Down syndrome live births were registered in the Taiwan Down Syndrome Association. A total of 466 cases (88·43 per cent) of Down syndrome live births occurred before age 35, which was higher than occidental reports. This study established the first sizeable database of maternal age‐specific risk for Down syndrome in an Asian population. © 1998 John Wiley & Sons, Ltd.
ISSN:0197-3851
1097-0223
DOI:10.1002/(SICI)1097-0223(199807)18:7<675::AID-PD319>3.0.CO;2-C