Effects of Sodium Nitroprusside on the Catecholamine Synthetic Pathway in the Adrenal Medulla of Rats

We studied the effect of sodium nitroprusside (SNP), a nitric oxide (NO) donor, on tyrosine hydroxylase (TH) activity and epinephrine and norepinephrine levels in the adrenal medulla of rats. TH activity and the levels of epinephrine and norepinephrine in the adrenal medulla of the SNP + nicotine (N...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1998, Vol.77(3), pp.205-210
Main Authors: Kumai, Toshio, Tanaka, Masami, Tateishi, Tomonori, Asoh, Masako, Kobayashi, Shinichi
Format: Article
Language:English
Subjects:
Adrenal medulla
Adrenal Medulla - drug effects
Adrenal Medulla - enzymology
Adrenal Medulla - metabolism
Animals
Catecholamine
Epinephrine - biosynthesis
Male
Nitric oxide
Nitroprusside - pharmacology
Norepinephrine - biosynthesis
Rats
Rats, Wistar
Sodium nitroprusside
Tyrosine 3-Monooxygenase - metabolism
Tyrosine hydroxylase
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Summary:We studied the effect of sodium nitroprusside (SNP), a nitric oxide (NO) donor, on tyrosine hydroxylase (TH) activity and epinephrine and norepinephrine levels in the adrenal medulla of rats. TH activity and the levels of epinephrine and norepinephrine in the adrenal medulla of the SNP + nicotine (Nic)-treated group were increased significantly compared to those in the control, Nic-treated and SNP-treated groups. Furthermore, methylene blue inhibited this increase in TH activity. The data suggest that the NO derived from SNP may increase TH through the guanylyl cyclase pathway in the presence of Nic.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.77.205