Resistance to HgCl2-Induced Autoimmunity in Haplotype-Heterozygous Mice Is an Intrinsic Property of B Cells

Exposure to low doses of mercury chloride induces autoantibodies to the nucleolar protein fibrillarin in H-2s, but not in H-2b, mice. Surprisingly, F1 crosses between resistant and sensitive haplotypes are resistant. Previously, we have shown that the resistance in these F1 mice was due to coexpress...

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Bibliographic Details
Published in:The Journal of immunology (1950) 1998-08, Vol.161 (4), p.1778-1785
Main Authors: Hanley, Gregory A, Schiffenbauer, Joel, Sobel, Eric S
Format: Article
Language:English
Subjects:
Animals
Antibodies, Antinuclear - biosynthesis
Autoimmune Diseases - genetics
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
B-Lymphocyte Subsets - immunology
B-Lymphocyte Subsets - metabolism
Cell Nucleolus - immunology
Chromosomal Proteins, Non-Histone - immunology
Crosses, Genetic
Haplotypes
Heterozygote
Histocompatibility Antigens Class II - genetics
Histocompatibility Antigens Class II - immunology
Humans
Immunity, Innate - drug effects
Immunity, Innate - genetics
Lymphocyte Cooperation - genetics
Mercuric Chloride - immunology
Mercuric Chloride - pharmacology
Mice
Mice, Inbred C57BL
Radiation Chimera - genetics
Radiation Chimera - immunology
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Helper-Inducer - metabolism
Thymus Gland - immunology
Thymus Gland - pathology
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Summary:Exposure to low doses of mercury chloride induces autoantibodies to the nucleolar protein fibrillarin in H-2s, but not in H-2b, mice. Surprisingly, F1 crosses between resistant and sensitive haplotypes are resistant. Previously, we have shown that the resistance in these F1 mice was due to coexpression of the resistant class II allele. Using adoptive transfer techniques we have examined several mechanisms by which the resistant haplotype could be down-regulating the antifibrillarin response in F1 (s/b) mice. Similar to other autoimmune models, mercury-induced autoimmunity requires cognate MHC-restricted T cell help. The absence of autoantibody production in F1 mice was not due to a difference in thymic education or to the absence of antifibrillarin-specific T cell help. These results suggest that the resistance is due to an intrinsic property of the haplotype-heterozygous B cells.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.161.4.1778