Pitx2 Participates in the Late Phase of the Pathway Controlling Left-Right Asymmetry

Pitx2, a member of the bicoid-related family of homeobox-containing genes, is asymmetrically expressed in the left lateral plate mesoderm and derived tissues during chick and mouse development. Modifications of Pitx2 pattern of expression in the iv mouse mutation correlate with the situs alterations...

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Bibliographic Details
Published in:Cell 1998-08, Vol.94 (3), p.319-324
Main Authors: Piedra, M.Elisa, Icardo, Jose M, Albajar, Marta, Rodriguez-Rey, Jose C, Ros, Maria A
Format: Article
Language:English
Subjects:
Animals
Body Patterning - genetics
Chick Embryo
Conserved Sequence
Gene Expression Regulation, Developmental
Homeobox Protein PITX2
Homeodomain Proteins - biosynthesis
Homeodomain Proteins - genetics
Homeodomain Proteins - physiology
Mesoderm - pathology
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Mutation
Nodal Protein
Nuclear Proteins
Paired Box Transcription Factors
Proteins - genetics
Proteins - physiology
Signal Transduction - genetics
Situs Inversus - genetics
Transcription Factors - biosynthesis
Transcription Factors - genetics
Transcription Factors - physiology
Transforming Growth Factor beta
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Summary:Pitx2, a member of the bicoid-related family of homeobox-containing genes, is asymmetrically expressed in the left lateral plate mesoderm and derived tissues during chick and mouse development. Modifications of Pitx2 pattern of expression in the iv mouse mutation correlate with the situs alterations characteristic of the mutation. Misexpression experiments demonstrate that Shh and nodal positively regulate Pitx2 expression. Our results are compatible with a Pitx2 function in the late phase of the gene cascade controlling laterality.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(00)81475-0