Collagenous gastritis revealed by severe anemia in a child

Collagenous gastritis is a rare histopathological disorder of unknown origin, characterized by a subepithelial collagen deposit greater than 10 μm thick, associated with an inflammatory infiltrate of the gastric mucosa. This report describes a second pediatric case of collagenous gastritis, revealed...

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Bibliographic Details
Published in:Human pathology 1998-08, Vol.29 (8), p.883-886
Main Authors: Côté, Jean-François, Hankard, Gaelle Fromont, Faure, Christophe, Mougenot, Jean-François, Holvoet, L, Cézard, Jean-Pierre, Navarro, Jean, Peuchmaur, Michel
Format: Article
Language:English
Subjects:
Anemia - diagnosis
Anemia - etiology
Biological and medical sciences
Biomarkers - analysis
Child
children
Collagen - metabolism
collagen diseases
Collagen Diseases - complications
Collagen Diseases - diagnosis
Collagen Diseases - metabolism
Female
Gastric Mucosa - metabolism
Gastric Mucosa - pathology
gastritis
Gastritis - complications
Gastritis - diagnosis
Gastritis - metabolism
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Hemorrhage - complications
Humans
Immunoenzyme Techniques
Medical sciences
Other diseases. Semiology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:Collagenous gastritis is a rare histopathological disorder of unknown origin, characterized by a subepithelial collagen deposit greater than 10 μm thick, associated with an inflammatory infiltrate of the gastric mucosa. This report describes a second pediatric case of collagenous gastritis, revealed by severe anemia caused by gastric bleeding, as was the first case. Unlike the adult cases of collagenous gastritis, lesions were limited to the stomach, and remained unchanged on six series of biopsies taken during a 30 month follow-up, despite treatment with omeprazole, sucralfate and corticosteroids. An immunohistochemical study showed signs of local immune activation on all biopsy specimens, including overexpression of HLA-DR by epithelial cells, increased numbers of CD3+ intraepithelial lymphocytes, and CD25+ cells in the lamina propria. Although the cause of the disease remains unclear, our findings suggest that the histopathological lesions of collagenous gastritis may result from a local immune process.
ISSN:0046-8177
1532-8392
DOI:10.1016/S0046-8177(98)90461-0