Characterization of wear debris associated with aseptic loosening of a canine hip prosthesis

A 12-month-old Golden Retriever bitch underwent unilateral hip arthroplasty following a diagnosis of coxofemoral osteoarthritis secondary to hip dysplasia. The hip prosthesis underwent aseptic loosening and was removed 6 months after implantation. Synovial biopsies taken at that time revealed scatte...

Full description

Saved in:
Bibliographic Details
Published in:Journal of comparative pathology 1998-07, Vol.119 (1), p.89-93
Main Authors: Day, M.J., Butterworth, S.J., Palmer, M.R., Case, C.P.
Format: Article
Language:English
Subjects:
Animals
Chromium - analysis
Cobalt - analysis
Dog Diseases - pathology
Dogs
Female
Hip Prosthesis - veterinary
Microscopy, Electron
Prosthesis Failure - veterinary
Synovial Membrane - chemistry
Synovial Membrane - pathology
Synovitis - pathology
Synovitis - veterinary
Titanium - analysis
Zirconium - analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A 12-month-old Golden Retriever bitch underwent unilateral hip arthroplasty following a diagnosis of coxofemoral osteoarthritis secondary to hip dysplasia. The hip prosthesis underwent aseptic loosening and was removed 6 months after implantation. Synovial biopsies taken at that time revealed scattered foci of granulomatous inflammation associated with intra-cytoplasmic and extracellular particulate material. Electron microscopical analyses demonstrated that this material contained cobalt, chromium, titanium and zirconium, which was probably wear debris from the loosened prosthesis. In human patients with hip arthroplasty, widespread dissemination of wear debris from loosened prostheses occasionally occurs, with an increased prevalence of neoplasia. A similar phenomenon may be predicted to occur with the increasing use of hip arthroplasty in the dog.
ISSN:0021-9975
1532-3129
DOI:10.1016/S0021-9975(98)80075-3