WA8242A1, A2 and B, Novel Secretary Phospholipase A2 Inhibitors Produced by Streptomyces violaceusniger: III. Structure Elucidation and Total Synthesis of WA8242B

The structure of WA8242B, a potent novel inhibitor against phospholipase A2, was fully characterized by spectroscopic methods and chemical degradation. The success of total synthesis of WA8242B confirmed the structure and allowed the pharmacological study of WA8242B. The structures of WA8242A1 and A...

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Bibliographic Details
Published in:Journal of antibiotics 1998/07/25, Vol.51(7), pp.655-664
Main Authors: YOSHIMURA, SEIJI, OTSUKA, TAKANAO, TAKASE, SHIGEHIRO, OKAMOTO, MASANORI, OKADA, SATOSHI, HEMMI, KEIJI
Format: Article
Language:English
Subjects:
Adipates - chemical synthesis
Adipates - chemistry
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - chemistry
Fundamental and applied biological sciences. Psychology
Magnetic Resonance Spectroscopy
Microbiology
Molecular Structure
Phospholipases A - antagonists & inhibitors
Phospholipases A2
Streptomyces - chemistry
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Summary:The structure of WA8242B, a potent novel inhibitor against phospholipase A2, was fully characterized by spectroscopic methods and chemical degradation. The success of total synthesis of WA8242B confirmed the structure and allowed the pharmacological study of WA8242B. The structures of WA8242A1 and A2 were also described.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.51.655