SENSITIVITY AND PERMEABILITY OF THE ANTHRAMYCIN PRODUCING ORGANISM STREPTOMYCES REFUINEUS TO ANTHRAMYCIN AND STRUCTURALLY RELATED ANTIBIOTICS

Streptomyces refuineus, the microorganism which produces the DNA reactive antibiotic anthramycin, has been shown to possess a quite specific mechanism to survive and grow in the presence of this antibiotic. Stationary phase cells are insensitive to anthramycin since the antibiotic is prevented from...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1981, Vol.34(9), pp.1171-1174
Main Authors: ROKEM, J. STEFAN, HURLEY, LAURENCE H.
Format: Article
Language:English
Subjects:
Aminoglycosides
Anthramycin - biosynthesis
Anthramycin - metabolism
Anthramycin - pharmacology
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - pharmacology
Antibiotics, Antineoplastic - pharmacology
Benzodiazepinones - pharmacology
Cell Membrane Permeability
Streptomyces - drug effects
Streptomyces - metabolism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Streptomyces refuineus, the microorganism which produces the DNA reactive antibiotic anthramycin, has been shown to possess a quite specific mechanism to survive and grow in the presence of this antibiotic. Stationary phase cells are insensitive to anthramycin since the antibiotic is prevented from entering these cells. However, cells in early log phase are inhibited by concentrations of anthramycin that are later produced by these same cells. Significantly, sibiromycin, a closely related antibiotic, is taken up by cells of S. refuineus independent of the age of the culture. Anthramycin reacts in vitro equally as well with DNA isolated from S. refuineus and other procaryotic and eucaryotic cells. When S. refuineus has reached the production phase the anthramycin is probably biosynthesized outside the cell membrane which also becomes specifically impermeable to anthramycin.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.34.1171