Effects of Losartan and Enalapril on Small Artery Structure in Hypertensive Rats

We evaluated the effects on cardiovascular structure of the angiotensin-converting enzyme (ACE) inhibitor enalapril and of the angiotensin II receptor blocker losartan, administered either at hypotensive or nonhypotensive dosage in spontaneously hypertensive rats (SHR). SHR were treated from ages 4...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1998-08, Vol.32 (2), p.305-310
Main Authors: Rizzoni, Damiano, Porteri, Enzo, Piccoli, Alfonso, Castellano, Maurizio, Bettoni, Giorgio, Muiesan, Maria Lorenza, Pasini, Giancarlo, Guelfi, Daniele, Mulvany, Michael J, Rosei, Enrico Agabiti
Format: Article
Language:English
Subjects:
Animals
Antihypertensive agents
Antihypertensive Agents - administration & dosage
Arteries - drug effects
Arteries - pathology
Arteries - physiopathology
Biological and medical sciences
Blood Pressure - drug effects
Cardiovascular system
Cell Division - drug effects
Dose-Response Relationship, Drug
Enalapril - administration & dosage
Heart Ventricles - drug effects
Heart Ventricles - pathology
Heart Ventricles - physiopathology
Hypertension - drug therapy
Hypertension - pathology
Hypertension - physiopathology
Losartan - administration & dosage
Medical sciences
Pharmacology. Drug treatments
Rats
Rats, Inbred SHR
Rats, Inbred WKY
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Summary:We evaluated the effects on cardiovascular structure of the angiotensin-converting enzyme (ACE) inhibitor enalapril and of the angiotensin II receptor blocker losartan, administered either at hypotensive or nonhypotensive dosage in spontaneously hypertensive rats (SHR). SHR were treated from ages 4 to 12 weeks with low-dose (1 mg [middle dot] kg [middle dot] d) enalapril, low-dose (0.5 mg [middle dot] kg () [middle dot] d) losartan, high-dose (25 mg [middle dot] kg [middle dot] d) enalapril, or high-dose (15 mg [middle dot] kg [middle dot] d) losartan. Untreated WKY and SHR were also studied. Rats were killed at 13 weeks of age, and the heart was weighed. Mesenteric small arteries were dissected and mounted on a micromyograph for determination of media thickness and lumen diameter. In fixed arteries, cell volume, number of cells per segment length, and number of cell layers were measured using the unbiased "disector" method. Systolic blood pressure was significantly reduced by the high doses of both drugs, but the hypotensive effect was greater with enalapril than with losartan (P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.32.2.305