The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome

The Drosophila gene dead ringer (dri) was isolated as a novel gene encoding a sequence-specific DNA-binding protein. DRI is a founding member of a growing protein family whose members share a conserved DNA binding domain termed the A/T-rich interaction domain. dri is developmentally regulated, being...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1998-07, Vol.51 (2), p.288-292
Main Authors: KORTSCHAK, R. D, REIMANN, H, ZIMMER, M, EYRE, H. J, SAINT, R, JENNE, D. E
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chromosome Mapping
Chromosomes, Human, Pair 19 - genetics
Cloning, Molecular
DNA, Complementary - genetics
DNA-Binding Proteins - genetics
Drosophila
Drosophila - genetics
Drosophila Proteins
Exons - genetics
Fundamental and applied biological sciences. Psychology
Genes, Regulator - genetics
Genes. Genome
HeLa Cells
Homeodomain Proteins - genetics
Humans
Introns - genetics
Male
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Nuclear Proteins - genetics
Oncogenes
Organ Specificity
Pedigree
Peutz-Jeghers Syndrome - genetics
Phylogeny
RNA, Messenger - analysis
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Trans-Activators - genetics
Transcription Factors
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Summary:The Drosophila gene dead ringer (dri) was isolated as a novel gene encoding a sequence-specific DNA-binding protein. DRI is a founding member of a growing protein family whose members share a conserved DNA binding domain termed the A/T-rich interaction domain. dri is developmentally regulated, being expressed in a restricted set of cells including some neural cells and differentiating cells of the gut and salivary gland ducts. The mouse homolog of dri, bright, has been shown to be expressed in mature B-cells in the immune system, its product trans-activating expression through an IgH enhancer in transient transfection assays. We have cloned a human dri/bright homolog, termed DRIL1. Here we report the exon-intron structure of the gene and show physical linkage within 80 kb to the D19S886 marker on 19p13.3. As this marker is intimately linked to the Peutz-Jeghers syndrome in several large pedigrees, human dri (DRIL1) is a candidate gene for this disorder.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1998.5259