4-Hydroxybenzoic acid: a hypoglycemic constituent of aqueous extract of Pandanus odorus root

Hypoglycemic activity-guided fraction led to the isolation of the known compound, 4-hydroxybenzoic acid, from Pandanus odorus Ridl. (Thai name: Toei-hom, Pandanaceae). This compound showed a hypoglycemic effect in normal rats after the oral administration of 5 mg/kg. Additionally, the compound incre...

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Bibliographic Details
Published in:Journal of ethnopharmacology 1998-08, Vol.62 (1), p.79-84
Main Authors: Peungvicha, Penchom, Temsiririrkkul, Rungravi, Prasain, Jeevan Kurmar, Tezuka, Yasuhiro, Kadota, Shigetoshi, Thirawarapan, Suwan S, Watanabe, Hiroshi
Format: Article
Language:English
Subjects:
4-Hydroxybenzoic acid
Animals
Biological and medical sciences
General pharmacology
hypoglycemic agents
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - pharmacology
Hypoglycemic effect
Insulin - blood
Liver Glycogen - metabolism
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Pandanus odorus
Parabens - chemistry
Parabens - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Rats
Rats, Wistar
toei-hom
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Summary:Hypoglycemic activity-guided fraction led to the isolation of the known compound, 4-hydroxybenzoic acid, from Pandanus odorus Ridl. (Thai name: Toei-hom, Pandanaceae). This compound showed a hypoglycemic effect in normal rats after the oral administration of 5 mg/kg. Additionally, the compound increased serum insulin levels and liver glycogen content in normal rats.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(98)00061-0