IL-4 inhibits P-glycoprotein in normal and malignant NK cells

Patients presenting with a natural killer (NK) cell leukemia generally have a poor prognosis. NK cell tumors are generally resistant to numerous chemotherapeutic drugs and even combination chemotherapy usually results in only short term remissions. The drug resistance of NK cell leukemias may be at...

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Bibliographic Details
Published in:Human immunology 1998-08, Vol.59 (8), p.483-487
Main Authors: Tambur, Anat R., Markham, Penelope N., Gebel, Howard M.
Format: Article
Language:English
Subjects:
ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors
ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism
Cell Line
Female
Flow Cytometry
Humans
Interleukin-4 - pharmacology
Killer Cells, Natural - drug effects
Killer Cells, Natural - metabolism
Killer Cells, Natural - pathology
Leukemia - drug therapy
Leukemia - metabolism
Leukemia - pathology
Middle Aged
Recombinant Proteins
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Summary:Patients presenting with a natural killer (NK) cell leukemia generally have a poor prognosis. NK cell tumors are generally resistant to numerous chemotherapeutic drugs and even combination chemotherapy usually results in only short term remissions. The drug resistance of NK cell leukemias may be at least partially explained by their expression of the multidrug resistant transporter, P-glycoprotein (Pgp). In this study, we demonstrate that the expression and function of Pgp activity on NK cells (leukemic and normal) can be reversed with IL-4.
ISSN:0198-8859
1879-1166
DOI:10.1016/S0198-8859(98)00042-1