Cystic renal cell carcinoma: Arose as a simple cyst, recurred repeatedly as a multicystic mass and finally presented as a solid mass

An unusual case of cystic renal cell carcinoma in a 70‐year‐old Japanese male is reported. He had had a simple renal cyst removed 1 year ago. On presentation the right kidney was surrounded by multiple translucent cysts, which varied in size from 1 to 50 mm. The cyst walls were lined by slngle‐layer...

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Bibliographic Details
Published in:Pathology international 1998-08, Vol.48 (8), p.623-628
Main Authors: Shishikura, Yuri, Furusato, Masakuni, Aizawa, Shigeo
Format: Article
Language:English
Subjects:
Aged
Aneuploidy
Carcinoma, Renal Cell - diagnostic imaging
Carcinoma, Renal Cell - pathology
Carcinoma, Renal Cell - surgery
cyst
Diagnosis, Differential
DNA, Neoplasm - analysis
Fatal Outcome
Flow Cytometry
granular cell
Humans
Immunoenzyme Techniques
Kidney Neoplasms - diagnostic imaging
Kidney Neoplasms - pathology
Kidney Neoplasms - surgery
Male
Neoplasm Invasiveness
Neoplasm Recurrence, Local - pathology
Polycystic Kidney Diseases - diagnostic imaging
Polycystic Kidney Diseases - pathology
Polycystic Kidney Diseases - surgery
renal cell carcinoma
Tomography, X-Ray Computed
ultra‐structure
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Summary:An unusual case of cystic renal cell carcinoma in a 70‐year‐old Japanese male is reported. He had had a simple renal cyst removed 1 year ago. On presentation the right kidney was surrounded by multiple translucent cysts, which varied in size from 1 to 50 mm. The cyst walls were lined by slngle‐layered cuboidal epithelium. The differential diagnosis included cystic mesothelioma, cystic lymphangioma and multlcystic dysplastic kidney. An immunohistochemical and ultrastructural study and flow cytometric analysis of DNA ploldy were performed. The tumor was dlfferentiated to such an extent that it was difficult to diagnose as carcinoma; however, it recurred repeatedly. Three and a half years after initial presentation the tumor had invaded the ileum with the pathological change to be almost solid when viewed grossly and, microscopically, showed tubulo‐papillary structures in addltlon to a cystic pattern. The DNA ploidy pattern revealed a near‐diploid aneuplold in the early specimen and a polyploid aneuploid in the last specimen.
ISSN:1320-5463
1440-1827
DOI:10.1111/j.1440-1827.1998.tb03960.x