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Differential impact of conventional oral or transdermal hormone replacement therapy or tibolone on body composition in postmenopausal women

OBJECTIVE To compare the effects on body composition and body weight of tibolone vs two different sequential oral or transdermal oestrogen‐progestogen hormone replacement therapies versus no therapy. PATIENTS AND METHODS One hundred postmenopausal women were assigned to a control group (n = 26), or...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 1998-06, Vol.48 (6), p.691-699
Main Authors: Hänggi, Willy, Lippuner, Kurt, Jaeger, Philippe, Birkhäuser, Martin H., Horber, Fritz F.
Format: Article
Language:English
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Summary:OBJECTIVE To compare the effects on body composition and body weight of tibolone vs two different sequential oral or transdermal oestrogen‐progestogen hormone replacement therapies versus no therapy. PATIENTS AND METHODS One hundred postmenopausal women were assigned to a control group (n = 26), or randomized to 1) tibolone (TIB) 2.5 mg/day (n = 28), 2) oral oestradiol 2 mg/day (PO) plus sequential dydrogesterone 10 mg/day for 14 of 28 days per cycle (n = 26), or 3) transdermal oestradiol patch (TTS) releasing 50 μg/day plus oral sequential dydrogesterone 10 mg/day for 14 of 28 days per cycle (n = 20). Body composition was measured at the baseline and every 6 months for 2 years by DXA (Hologic QDR 1000 W). RESULTS Total body fat mass increased (P 
ISSN:0300-0664
1365-2265
DOI:10.1046/j.1365-2265.1998.00481.x