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Differential impact of conventional oral or transdermal hormone replacement therapy or tibolone on body composition in postmenopausal women
OBJECTIVE To compare the effects on body composition and body weight of tibolone vs two different sequential oral or transdermal oestrogen‐progestogen hormone replacement therapies versus no therapy. PATIENTS AND METHODS One hundred postmenopausal women were assigned to a control group (n = 26), or...
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Published in: | Clinical endocrinology (Oxford) 1998-06, Vol.48 (6), p.691-699 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | OBJECTIVE
To compare the effects on body composition and body weight of tibolone vs two different sequential oral or transdermal oestrogen‐progestogen hormone replacement therapies versus no therapy.
PATIENTS AND METHODS
One hundred postmenopausal women were assigned to a control group (n = 26), or randomized to 1) tibolone (TIB) 2.5 mg/day (n = 28), 2) oral oestradiol 2 mg/day (PO) plus sequential dydrogesterone 10 mg/day for 14 of 28 days per cycle (n = 26), or 3) transdermal oestradiol patch (TTS) releasing 50 μg/day plus oral sequential dydrogesterone 10 mg/day for 14 of 28 days per cycle (n = 20). Body composition was measured at the baseline and every 6 months for 2 years by DXA (Hologic QDR 1000 W).
RESULTS
Total body fat mass increased (P |
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ISSN: | 0300-0664 1365-2265 |
DOI: | 10.1046/j.1365-2265.1998.00481.x |