State-Dependent Stimulus Control: Cuing Attributes of Acute Cocaine Rebound in Rats

Sprague-Dawley ( Rattus norvegicus ) rats were trained in a drug discrimination task using the state-dependent interoceptive stimulus attributes of cocaine's delayed or rebound effects (CDE) versus "normal" basal homeostasis. Rats were injected with either 32 mg/kg cocaine or equivale...

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Bibliographic Details
Published in:Experimental and clinical psychopharmacology 1998-08, Vol.6 (3), p.264-273
Main Authors: Gauvin, David V, Vanecek, Susan A, Baird, Theodore J, Briscoe, Richard J, Vallett, Mary, Carl, Kathy L, Wasielewski, Jill A, Holloway, Frank A
Format: Article
Language:English
Subjects:
Animal
Animals
Chlordiazepoxide - pharmacology
Cocaine
Cocaine - blood
Cocaine - pharmacology
Discrimination (Psychology)
Drug Dependency
Drug Discrimination
Lidocaine - pharmacology
Male
N-Methylaspartate - pharmacology
Narcotics - blood
Narcotics - pharmacology
Rats
Rats, Sprague-Dawley
Self Administration
Stimulus Parameters
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Summary:Sprague-Dawley ( Rattus norvegicus ) rats were trained in a drug discrimination task using the state-dependent interoceptive stimulus attributes of cocaine's delayed or rebound effects (CDE) versus "normal" basal homeostasis. Rats were injected with either 32 mg/kg cocaine or equivalent volumes of saline (SAL), subcutaneously, 13 hr before the sessions. Rats demonstrated >90% discriminative accuracy. Test sessions showed a time-dependent acute cocaine isodirectional rebound state that engendered a shift from predominantly SAL- to CDE-appropriate responding approximately 7 hr after the high training dose injection and lasted for approximately 10 hr (17 hr postinjection). The delayed or rebound state was dose dependent and engendered only a biphasic partial generalization with acute cocaine injections. There were no detectable levels of cocaine or any of its behaviorally active metabolites at the 13-hr postinjection interval. Tests conducted with various doses of lidocaine, chlordiazepoxide, N -methyl- d -aspartic acid, ketamine, and buspirone engendered SAL- or default-appropriate responding. The anxiogenic drug, pentylenetetrazole, produced partial generalization to the cocaine rebound cue.
ISSN:1064-1297
1936-2293
DOI:10.1037/1064-1297.6.3.264