State-Dependent Stimulus Control: Cuing Attributes of Acute Cocaine Rebound in Rats

• Published in: Experimental and clinical psychopharmacology 1998-08, Vol.6 (3), p.264-273
• Main Authors: Gauvin, David V, Vanecek, Susan A, Baird, Theodore J, Briscoe, Richard J, Vallett, Mary, Carl, Kathy L, Wasielewski, Jill A, Holloway, Frank A
• Format: Article
• Language: English
• Subjects: Animal; Animals; Chlordiazepoxide - pharmacology; Cocaine; Cocaine - blood; Cocaine - pharmacology; Discrimination (Psychology); Drug Dependency; Drug Discrimination; Lidocaine - pharmacology; Male; N-Methylaspartate - pharmacology; Narcotics - blood; Narcotics - pharmacology; Rats; Rats, Sprague-Dawley; Self Administration; Stimulus Parameters
• ISSN: 1064-1297; 1936-2293
• DOI: 10.1037/1064-1297.6.3.264

Sprague-Dawley ( Rattus norvegicus ) rats were trained in a drug discrimination task using the state-dependent interoceptive stimulus attributes of cocaine's delayed or rebound effects (CDE) versus "normal" basal homeostasis. Rats were injected with either 32 mg/kg cocaine or equivalent volumes of saline (SAL), subcutaneously, 13 hr before the sessions. Rats demonstrated >90% discriminative accuracy. Test sessions showed a time-dependent acute cocaine isodirectional rebound state that engendered a shift from predominantly SAL- to CDE-appropriate responding approximately 7 hr after the high training dose injection and lasted for approximately 10 hr (17 hr postinjection). The delayed or rebound state was dose dependent and engendered only a biphasic partial generalization with acute cocaine injections. There were no detectable levels of cocaine or any of its behaviorally active metabolites at the 13-hr postinjection interval. Tests conducted with various doses of lidocaine, chlordiazepoxide, N -methyl- d -aspartic acid, ketamine, and buspirone engendered SAL- or default-appropriate responding. The anxiogenic drug, pentylenetetrazole, produced partial generalization to the cocaine rebound cue.