A novel treatment for venous leg ulcers

Venous ulceration, a relatively common manifestation of venous hypertension, is often difficult to treat. This article reports the authors' experience with a new wound-healing technology using a bilayered, culture-derived human skin equivalent (HSE, Apligraf™) 5 for treatment of venous ulcers....

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Bibliographic Details
Published in:The Journal of foot and ankle surgery 1998-07, Vol.37 (4), p.319-324
Main Authors: Alvarez, Oscar M., Fahey, Catherine B., Auletta, Michael J., Fernández-Obregón, Adolfo
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
artificial skin
Bandages
Biological and medical sciences
Cells, Cultured
Collagen
Combined Modality Therapy
Female
human skin equivalent
Humans
Leg Ulcer - physiopathology
Leg Ulcer - therapy
Male
Medical sciences
Pressure
skin graft
Skin plastic surgery
Skin Transplantation - methods
Skin, Artificial
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
venous ulcers
Wound Healing
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Summary:Venous ulceration, a relatively common manifestation of venous hypertension, is often difficult to treat. This article reports the authors' experience with a new wound-healing technology using a bilayered, culture-derived human skin equivalent (HSE, Apligraf™) 5 for treatment of venous ulcers. In the patients studied, HSE appeared to promote wound healing in three ways: 1) apparent graft “take”; 2) temporary wound closure (persistence of HSE with subsequent wound re-epithelialization from wound margins); and 3) stimulation of host healing without temporary persistence by acting as a biologic dressing. The demonstrated efficacy of HSE suggests that it will prove useful for promoting the healing of venous ulcers.
ISSN:1067-2516
1542-2224
DOI:10.1016/S1067-2516(98)80069-0