Fine-needle aspiration biopsy of metastatic small cell carcinoma from extrapulmonary sites

Like a pulmonary counterpart, extrapulmonary small cell carcinoma (SCC) is an aggressive tumor with a high rate of metastasis. Forty‐nine fine‐needle aspiration biopsies (FNABs) (36 patients) of various primary sites other than the lung diagnosed as metastatic SCC (including Merkel cell carcinoma) w...

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Bibliographic Details
Published in:Diagnostic cytopathology 1998-09, Vol.19 (3), p.177-181
Main Authors: Shin, Hyung Ju C., Caraway, Nancy P.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - analysis
Biopsy, Needle
Carcinoma, Merkel Cell - chemistry
Carcinoma, Merkel Cell - pathology
Carcinoma, Small Cell - chemistry
Carcinoma, Small Cell - secondary
extrapulmonary small cell carcinoma
Female
fine-needle aspiration biopsy
Humans
Immunoenzyme Techniques
Investigative techniques, diagnostic techniques (general aspects)
Lung Neoplasms - pathology
Male
Medical sciences
Merkel cell carcinoma
metastasis
Middle Aged
Miscellaneous. Technology
Neoplasms - chemistry
Neoplasms - pathology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Citations: Items that this one cites
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Summary:Like a pulmonary counterpart, extrapulmonary small cell carcinoma (SCC) is an aggressive tumor with a high rate of metastasis. Forty‐nine fine‐needle aspiration biopsies (FNABs) (36 patients) of various primary sites other than the lung diagnosed as metastatic SCC (including Merkel cell carcinoma) were reviewed. FNABs were derived from lymph nodes (20), liver (7), bone (2), breast (1), pancreas (1), and skin/soft tissue (18). Primary tumor sites included the prostate (14), skin (11; Merkel cell carcinoma), cervix (5), urinary bladder (3), urethra (1), ovary (1), and parotid (1). Aspirates revealed predominantly dispersed single tumor cells with occasional clustering. Tumor cells were small with scant cytoplasm, fine powdery chromatin, and inconspicuous nucleoli. Nuclear molding, mitotic figures, and apoptotic bodies were frequently observed. In four cases, findings from the FNABs were used to render the initial diagnosis of SCC. FNAB is useful for determining whether metastases contain a SCC component, a finding that may alter clinical management. Cytologically, SCC from different primary sites cannot be differentiated, and its distinction requires clinical and radiographic correlation. Diagn. Cytopathol. 1998;19:177–181. © 1998 Wiley‐Liss, Inc.
ISSN:8755-1039
1097-0339
DOI:10.1002/(SICI)1097-0339(199809)19:3<177::AID-DC4>3.0.CO;2-A