Stress-inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection

Molecular chaperones protect proteins against environmental and physiologic stress and from the deleterious consequences of an imbalance in protein homeostasis. Many of these stresses, if prolonged, result in defective development and pathologies associated with a diverse array of diseases due to ti...

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Bibliographic Details
Published in:Nature biotechnology 1998-09, Vol.16 (9), p.833-838
Main Authors: Morimoto, Richard I, Santoro, M.Gabriella
Format: Article
Language:English
Subjects:
Agriculture
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Benzoquinones
Bioinformatics
Biological and medical sciences
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Cell Survival - drug effects
Drug Design
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Heat-Shock Proteins - genetics
Heat-Shock Proteins - physiology
Heat-Shock Response
Humans
Hydroxylamine - pharmacology
Industrial applications and implications. Economical aspects
Lactams, Macrocyclic
Life Sciences
Miscellaneous
Oxidative Stress - drug effects
Quinones - pharmacology
research-review
Rifabutin - analogs & derivatives
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Summary:Molecular chaperones protect proteins against environmental and physiologic stress and from the deleterious consequences of an imbalance in protein homeostasis. Many of these stresses, if prolonged, result in defective development and pathologies associated with a diverse array of diseases due to tissue injury and repair including stroke, myocardial reperfusion damage, ischemia, cancer, amyloidosis, and other neurodegenerative diseases. We discuss the molecular nature of the stress signals, the mechanisms that underlie activation of the heat shock response, the role of heat shock proteins as cytoprotective molecules, and strategies for pharmacologically active molecules as regulators of the heat shock response.
ISSN:1087-0156
1546-1696
DOI:10.1038/nbt0998-833