Loading…
Stress-inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection
Molecular chaperones protect proteins against environmental and physiologic stress and from the deleterious consequences of an imbalance in protein homeostasis. Many of these stresses, if prolonged, result in defective development and pathologies associated with a diverse array of diseases due to ti...
Saved in:
| Published in: | Nature biotechnology 1998-09, Vol.16 (9), p.833-838 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c407t-f5a1e10e3a7693099dae1c2a24dec8f35f76cc50783d6adf5e70ce7a4ec734e93 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c407t-f5a1e10e3a7693099dae1c2a24dec8f35f76cc50783d6adf5e70ce7a4ec734e93 |
| container_end_page | 838 |
| container_issue | 9 |
| container_start_page | 833 |
| container_title | Nature biotechnology |
| container_volume | 16 |
| creator | Morimoto, Richard I Santoro, M.Gabriella |
| description | Molecular chaperones protect proteins against environmental and physiologic stress and from the deleterious consequences of an imbalance in protein homeostasis. Many of these stresses, if prolonged, result in defective development and pathologies associated with a diverse array of diseases due to tissue injury and repair including stroke, myocardial reperfusion damage, ischemia, cancer, amyloidosis, and other neurodegenerative diseases. We discuss the molecular nature of the stress signals, the mechanisms that underlie activation of the heat shock response, the role of heat shock proteins as cytoprotective molecules, and strategies for pharmacologically active molecules as regulators of the heat shock response. |
| doi_str_mv | 10.1038/nbt0998-833 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73885115</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73885115</sourcerecordid><originalsourceid>FETCH-LOGICAL-c407t-f5a1e10e3a7693099dae1c2a24dec8f35f76cc50783d6adf5e70ce7a4ec734e93</originalsourceid><addsrcrecordid>eNqFkk1PFTEUhhsjQUBWrk1qYtzoSEu_ZtwZgkpCdAGsx3M7Z-4dmNteezox_HsKd4JuCKu2eZ-8J-dJGXsjxWcpVH0UFlk0TV3VSr1ge9JoW0nb2JflLmpXCWnsK7ZPdC2EsNraXbbbOK2kNHvs90VOSFQNoZv8sBiRl-cmBkLiEDq-QsicVtHf8E2KGYdAX_hP_Ms3K0hr8HGMy8HzDGmJmXgfE_e3OT6wPg8xvGY7PYyEh_N5wK6-nV6e_KjOf30_O_l6XnktXK56AxKlQAXONqqs0wFKfwzHukNf98r0znpvhKtVZ6HrDTrh0YFG75TGRh2wD9veMvrPhJTb9UAexxECxolap-ralJWfBaXVjRXGFfDjFvQpEiXs200a1pBuWynae_HtLL4t4gv9dq6dFmvsHtnZdMnfzzmQh7FPEPxA_yqtdo2-xz5tMSpJWGJqr-OUQjH3xNR3WzxAnhI-1v33JdQdO4SnFw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16496057</pqid></control><display><type>article</type><title>Stress-inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection</title><source>Nature</source><creator>Morimoto, Richard I ; Santoro, M.Gabriella</creator><creatorcontrib>Morimoto, Richard I ; Santoro, M.Gabriella</creatorcontrib><description>Molecular chaperones protect proteins against environmental and physiologic stress and from the deleterious consequences of an imbalance in protein homeostasis. Many of these stresses, if prolonged, result in defective development and pathologies associated with a diverse array of diseases due to tissue injury and repair including stroke, myocardial reperfusion damage, ischemia, cancer, amyloidosis, and other neurodegenerative diseases. We discuss the molecular nature of the stress signals, the mechanisms that underlie activation of the heat shock response, the role of heat shock proteins as cytoprotective molecules, and strategies for pharmacologically active molecules as regulators of the heat shock response.</description><identifier>ISSN: 1087-0156</identifier><identifier>EISSN: 1546-1696</identifier><identifier>DOI: 10.1038/nbt0998-833</identifier><identifier>PMID: 9743115</identifier><identifier>CODEN: NABIF9</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Agriculture ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Benzoquinones ; Bioinformatics ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedical Engineering/Biotechnology ; Biomedicine ; Biotechnology ; Cell Survival - drug effects ; Drug Design ; Fundamental and applied biological sciences. Psychology ; Health. Pharmaceutical industry ; Heat-Shock Proteins - genetics ; Heat-Shock Proteins - physiology ; Heat-Shock Response ; Humans ; Hydroxylamine - pharmacology ; Industrial applications and implications. Economical aspects ; Lactams, Macrocyclic ; Life Sciences ; Miscellaneous ; Oxidative Stress - drug effects ; Quinones - pharmacology ; research-review ; Rifabutin - analogs & derivatives</subject><ispartof>Nature biotechnology, 1998-09, Vol.16 (9), p.833-838</ispartof><rights>Nature Publishing Company 1998</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-f5a1e10e3a7693099dae1c2a24dec8f35f76cc50783d6adf5e70ce7a4ec734e93</citedby><cites>FETCH-LOGICAL-c407t-f5a1e10e3a7693099dae1c2a24dec8f35f76cc50783d6adf5e70ce7a4ec734e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1647945$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9743115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morimoto, Richard I</creatorcontrib><creatorcontrib>Santoro, M.Gabriella</creatorcontrib><title>Stress-inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection</title><title>Nature biotechnology</title><addtitle>Nat Biotechnol</addtitle><addtitle>Nat Biotechnol</addtitle><description>Molecular chaperones protect proteins against environmental and physiologic stress and from the deleterious consequences of an imbalance in protein homeostasis. Many of these stresses, if prolonged, result in defective development and pathologies associated with a diverse array of diseases due to tissue injury and repair including stroke, myocardial reperfusion damage, ischemia, cancer, amyloidosis, and other neurodegenerative diseases. We discuss the molecular nature of the stress signals, the mechanisms that underlie activation of the heat shock response, the role of heat shock proteins as cytoprotective molecules, and strategies for pharmacologically active molecules as regulators of the heat shock response.</description><subject>Agriculture</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Benzoquinones</subject><subject>Bioinformatics</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering/Biotechnology</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Cell Survival - drug effects</subject><subject>Drug Design</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health. Pharmaceutical industry</subject><subject>Heat-Shock Proteins - genetics</subject><subject>Heat-Shock Proteins - physiology</subject><subject>Heat-Shock Response</subject><subject>Humans</subject><subject>Hydroxylamine - pharmacology</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>Lactams, Macrocyclic</subject><subject>Life Sciences</subject><subject>Miscellaneous</subject><subject>Oxidative Stress - drug effects</subject><subject>Quinones - pharmacology</subject><subject>research-review</subject><subject>Rifabutin - analogs & derivatives</subject><issn>1087-0156</issn><issn>1546-1696</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkk1PFTEUhhsjQUBWrk1qYtzoSEu_ZtwZgkpCdAGsx3M7Z-4dmNteezox_HsKd4JuCKu2eZ-8J-dJGXsjxWcpVH0UFlk0TV3VSr1ge9JoW0nb2JflLmpXCWnsK7ZPdC2EsNraXbbbOK2kNHvs90VOSFQNoZv8sBiRl-cmBkLiEDq-QsicVtHf8E2KGYdAX_hP_Ms3K0hr8HGMy8HzDGmJmXgfE_e3OT6wPg8xvGY7PYyEh_N5wK6-nV6e_KjOf30_O_l6XnktXK56AxKlQAXONqqs0wFKfwzHukNf98r0znpvhKtVZ6HrDTrh0YFG75TGRh2wD9veMvrPhJTb9UAexxECxolap-ralJWfBaXVjRXGFfDjFvQpEiXs200a1pBuWynae_HtLL4t4gv9dq6dFmvsHtnZdMnfzzmQh7FPEPxA_yqtdo2-xz5tMSpJWGJqr-OUQjH3xNR3WzxAnhI-1v33JdQdO4SnFw</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>Morimoto, Richard I</creator><creator>Santoro, M.Gabriella</creator><general>Nature Publishing Group US</general><general>Nature</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19980901</creationdate><title>Stress-inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection</title><author>Morimoto, Richard I ; Santoro, M.Gabriella</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-f5a1e10e3a7693099dae1c2a24dec8f35f76cc50783d6adf5e70ce7a4ec734e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Agriculture</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Benzoquinones</topic><topic>Bioinformatics</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering/Biotechnology</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Cell Survival - drug effects</topic><topic>Drug Design</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health. Pharmaceutical industry</topic><topic>Heat-Shock Proteins - genetics</topic><topic>Heat-Shock Proteins - physiology</topic><topic>Heat-Shock Response</topic><topic>Humans</topic><topic>Hydroxylamine - pharmacology</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>Lactams, Macrocyclic</topic><topic>Life Sciences</topic><topic>Miscellaneous</topic><topic>Oxidative Stress - drug effects</topic><topic>Quinones - pharmacology</topic><topic>research-review</topic><topic>Rifabutin - analogs & derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morimoto, Richard I</creatorcontrib><creatorcontrib>Santoro, M.Gabriella</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morimoto, Richard I</au><au>Santoro, M.Gabriella</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stress-inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection</atitle><jtitle>Nature biotechnology</jtitle><stitle>Nat Biotechnol</stitle><addtitle>Nat Biotechnol</addtitle><date>1998-09-01</date><risdate>1998</risdate><volume>16</volume><issue>9</issue><spage>833</spage><epage>838</epage><pages>833-838</pages><issn>1087-0156</issn><eissn>1546-1696</eissn><coden>NABIF9</coden><abstract>Molecular chaperones protect proteins against environmental and physiologic stress and from the deleterious consequences of an imbalance in protein homeostasis. Many of these stresses, if prolonged, result in defective development and pathologies associated with a diverse array of diseases due to tissue injury and repair including stroke, myocardial reperfusion damage, ischemia, cancer, amyloidosis, and other neurodegenerative diseases. We discuss the molecular nature of the stress signals, the mechanisms that underlie activation of the heat shock response, the role of heat shock proteins as cytoprotective molecules, and strategies for pharmacologically active molecules as regulators of the heat shock response.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>9743115</pmid><doi>10.1038/nbt0998-833</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1087-0156 |
| ispartof | Nature biotechnology, 1998-09, Vol.16 (9), p.833-838 |
| issn | 1087-0156 1546-1696 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73885115 |
| source | Nature |
| subjects | Agriculture Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Benzoquinones Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Cell Survival - drug effects Drug Design Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Heat-Shock Proteins - genetics Heat-Shock Proteins - physiology Heat-Shock Response Humans Hydroxylamine - pharmacology Industrial applications and implications. Economical aspects Lactams, Macrocyclic Life Sciences Miscellaneous Oxidative Stress - drug effects Quinones - pharmacology research-review Rifabutin - analogs & derivatives |
| title | Stress-inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T12%3A14%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stress-inducible%20responses%20and%20heat%20shock%20proteins:%20New%20pharmacologic%20targets%20for%20cytoprotection&rft.jtitle=Nature%20biotechnology&rft.au=Morimoto,%20Richard%20I&rft.date=1998-09-01&rft.volume=16&rft.issue=9&rft.spage=833&rft.epage=838&rft.pages=833-838&rft.issn=1087-0156&rft.eissn=1546-1696&rft.coden=NABIF9&rft_id=info:doi/10.1038/nbt0998-833&rft_dat=%3Cproquest_cross%3E73885115%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c407t-f5a1e10e3a7693099dae1c2a24dec8f35f76cc50783d6adf5e70ce7a4ec734e93%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=16496057&rft_id=info:pmid/9743115&rfr_iscdi=true |