Calcium supplements increase the serum levels of crosslinked N-telopeptides of bone collagen and parathyroid hormone in rachitic Nigerian children

Objectives: Biochemical markers of bone turnover were measured in the sera of 16 controls and 10 children with calcium-deficiency rickets, during a 12-week course of calcium supplementation (1 g CaCO 3/d) that was effective in healing the bone lesions of the rachitic children. Design and methods: Se...

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Bibliographic Details
Published in:Clinical biochemistry 1998-07, Vol.31 (5), p.421-427
Main Authors: Scariano, John K, VanderJagt, Dorothy J, Thacher, Tom, Isichei, Christian O, Hollis, Bruce W, Glew, Robert H
Format: Article
Language:English
Subjects:
alkaline phosphatase
Alkaline Phosphatase - blood
Amino Acids - urine
Biomarkers - blood
Biomarkers - urine
Bone and Bones - metabolism
bone collagen
bone markers
Calcium - blood
Calcium - deficiency
Calcium - therapeutic use
Calcium Chloride - therapeutic use
Child
Child, Preschool
children
Collagen - blood
Collagen Type I
Creatinine - urine
deoxypyridinoline
Enzyme-Linked Immunosorbent Assay - methods
Female
Food, Fortified
Humans
Male
Nigeria
parathyroid hormone
Parathyroid Hormone - blood
Peptides - blood
Phosphorus - blood
Radioimmunoassay - methods
Reference Values
Regression Analysis
rickets
Rickets - blood
Rickets - drug therapy
Rickets - urine
serum NTx
Time Factors
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Summary:Objectives: Biochemical markers of bone turnover were measured in the sera of 16 controls and 10 children with calcium-deficiency rickets, during a 12-week course of calcium supplementation (1 g CaCO 3/d) that was effective in healing the bone lesions of the rachitic children. Design and methods: Serum levels of crosslinked N-telopeptides of bone collagen (NTx), parathyroid hormone (PTH), alkaline phosphatase (ALP), and urinary deoxypyridinoline (LP) were assayed at baseline and during the course of calcium therapy and compared with data of the 16 non-rachitic controls. Results: Calcium therapy suppressed serum NTx and PTH levels in the rachitic children within 24 h; however, after the first week, PTH and NTx levels increased to the extent that at 12 weeks both were elevated when compared with controls or to baseline levels. Serum levels of NTx and PTH were correlated in the controls and experimental subjects ( r = 0.63, p < 0.001). Conclusions: The rate of bone resorption, as estimated by serum NTx concentration, is increased during the healing of rachitic lesions.
ISSN:0009-9120
1873-2933
DOI:10.1016/S0009-9120(98)00031-9