Tree‐pollen allergy is efficiently treated by short‐term immunotherapy (STI) with seven preseasonal injections of molecular standardized allergens

The efficacy and tolerance of short‐term immunotherapy (STI) by seven preseasonal injections of tree‐pollen allergens (ALK7 FrUhbltihermischung®) was investigated in a double‐blind, placebo‐controlled, multicenter study with 111 rhinoconjunctivitis patients. Nasal and bronchial symptoms simultaneous...

Full description

Saved in:
Bibliographic Details
Published in:Allergy (Copenhagen) 1998-08, Vol.53 (8), p.740-748
Main Authors: Balda, B. R., Wolf, H., Baumgarten, C., Klimek, L., Rasp, G., Kunkel, G., Müller, S., Mann, W., Hauswald, B., Heppt, W., Przybilla, B., Amon, U., Bischoff, R., Becher, G., Hummel, S., Frosch, P. J., Rustemeyer, T., Jäger, L., Brehler, R., Schnitker, J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Allergens - immunology
Allergic diseases
allergic rhinitis
Biological and medical sciences
Blood Proteins - metabolism
Conjunctivitis, Allergic - therapy
Desensitization, Immunologic - adverse effects
Double-Blind Method
eosinophil cationic protein
Eosinophil Granule Proteins
Female
Humans
Immunoglobulin E - blood
Immunoglobulin G - blood
Immunopathology
Injections
Male
Medical sciences
Middle Aged
Pollen - immunology
Respiratory and ent allergic diseases
Rhinitis, Allergic, Seasonal - therapy
Ribonucleases
short‐term immunotherapy
skin prick titration
Skin Tests
specific IgE
specific IgG4
Time Factors
Treatment Outcome
tree pollen
Trees - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The efficacy and tolerance of short‐term immunotherapy (STI) by seven preseasonal injections of tree‐pollen allergens (ALK7 FrUhbltihermischung®) was investigated in a double‐blind, placebo‐controlled, multicenter study with 111 rhinoconjunctivitis patients. Nasal and bronchial symptoms simultaneously analyzed, and nasal symptoms as a single end point, but not the overall score of nasal, bronchial, and conjunctival symptoms, showed a significantly lower increase with STI during birch‐pollen exposure (both P= 0.033, n= 105, Mann‐Whitney U‐test). However, a selective analysis with patients from centers with high recruitment figures (nS10 patients, n=29 STI, n=32 placebo) showed a significantly lower increase of nasal, bronchial, and overall symptom score (STI 11.0 vs placebo 18.0, P=0.001, U‐test). STI had equidirected effects on conjunctival, nasal, and bronchial symptoms analyzed as multiple end points, although conjunctival symptoms were not significantly different as a single end point. The seasonal increase in drug use was reduced by 62% in the STI group compared with placebo (P=0.032, Mest), Specific IgG4 increased only after STI (P
ISSN:0105-4538
1398-9995
DOI:10.1111/j.1398-9995.1998.tb03969.x