Clinical Usefulness of Amikacin and Doxycycline in the Treatment of Infection Due to Mycobacterium fortuitum and Mycobacterium chelonei

The antimicrobial agents amikacin and doxycycline, which are not conventionally considered for use in treatment of mycobacterial infections, inhibit growth of Mycobacterium fortuitum and Mycobacterium chelonei in vitro. Ten patients were treated with these drugs alone or in combination with some sur...

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Bibliographic Details
Published in:Reviews of infectious diseases 1981-09, Vol.3 (5), p.1068-1074
Main Authors: Dalovisio, J R, Pankey, G A, Wallace, R J, Jones, D B
Format: Article
Language:English
Subjects:
Abscesses
Adult
Aged
Amikacin - therapeutic use
Antimicrobials
Child, Preschool
Debridement
Doxycycline - therapeutic use
Female
Humans
Infections
Kanamycin - analogs & derivatives
Lesions
Lungs
Male
Middle Aged
Mycobacterium chelonae
Mycobacterium fortuitum
Mycobacterium Infections - drug therapy
Mycobacterium Infections, Nontuberculous - drug therapy
Nontuberculous Mycobacteria - drug effects
Session VI: Clinical Aspects
Sinuses
White people
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Summary:The antimicrobial agents amikacin and doxycycline, which are not conventionally considered for use in treatment of mycobacterial infections, inhibit growth of Mycobacterium fortuitum and Mycobacterium chelonei in vitro. Ten patients were treated with these drugs alone or in combination with some surgical procedure. Seven of the 10 patients were definitely cured by the therapy. Only one definite treatment failure occurred. Patients with infections due to M. fortuitum or M. chelonei that are susceptible in vitro to these drugs appear to benefit from chemotherapy.
ISSN:0162-0886