Presence of Matrix Metalloproteinase-9 Activity in the Cerebrospinal Fluid of Human Immunodeficiency Virus—Infected Patients

To determine whether matrix metalloproteinase (MMP)-9 is a potential mediator involved in the frequently detected blood-brain barrier leakage in human immunodeficiency virus (HIV)-infected patients, zymography was used to detect MMP-9 activity in cerebrospinal fluid (CSF) samples of 80 HIV-infected...

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Bibliographic Details
Published in:The Journal of infectious diseases 1998-09, Vol.178 (3), p.854-857
Main Authors: Sporer, Bernd, Paul, Robert, Koedel, Uwe, Grimm, Roland, Wick, Manfred, Goebel, Frank D., Pfister, Hans-W.
Format: Article
Language:English
Subjects:
AIDS/HIV
Albumins
Biological and medical sciences
CD4 Lymphocyte Count
Central nervous system
Central nervous system diseases
Cerebrospinal fluid
Collagenases - cerebrospinal fluid
Concise Comunications
HIV
HIV infections
HIV Infections - blood
HIV Infections - cerebrospinal fluid
HIV Infections - enzymology
Human immunodeficiency virus 1
Human viral diseases
Humans
Infectious diseases
Leukocytes
Matrix Metalloproteinase 9
Medical sciences
Neurologic manifestations
Opportunistic behavior
Pathology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:To determine whether matrix metalloproteinase (MMP)-9 is a potential mediator involved in the frequently detected blood-brain barrier leakage in human immunodeficiency virus (HIV)-infected patients, zymography was used to detect MMP-9 activity in cerebrospinal fluid (CSF) samples of 80 HIV-infected patients and of 10 control patients. CSF MMP-9 activity was detected in 40% of HIV-infected patients (but not in controls) and was significantly more frequent in HIV-infected patients than in those without neurologic deficits (50% vs. 13.6%). The frequency of CSF MMP-9 activity did not significantly differ between neurologically symptomatic HIV-infected patients with or without opportunistic central nervous system disease (51.6% vs. 48.1%). Additionally, the presence of CSF MMP-9 activity in HIV-infected patients was associated with an increased CSF white blood cell count and an elevated CSF-to-serum albumin ratio, suggesting that it may play a role in blood-brain/CSF barrier leakage in HIV-infected patients.
ISSN:0022-1899
1537-6613
DOI:10.1086/515342