NMR methods in combinatorial chemistry

The use of NMR spectroscopy in combinatorial chemistry has provided a versatile tool for monitoring combinatorial chemistry reactions and for assessing ligand-receptor interactions. The application of magic angle spinning NMR is widespread and has allowed structure determination to be performed on c...

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Bibliographic Details
Published in:Current opinion in chemical biology 1998-06, Vol.2 (3), p.372-375
Main Authors: Shapiro, Michael J, Wareing, James R
Format: Article
Language:English
Subjects:
Chemistry, Organic - methods
Chromatography, High Pressure Liquid
Indicators and Reagents
Mass Spectrometry
Nuclear Magnetic Resonance, Biomolecular - methods
Resins, Plant
Solutions
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Summary:The use of NMR spectroscopy in combinatorial chemistry has provided a versatile tool for monitoring combinatorial chemistry reactions and for assessing ligand-receptor interactions. The application of magic angle spinning NMR is widespread and has allowed structure determination to be performed on compounds attached to solid supports. A variety of two-dimensional NMR techniques have been applied to enhance the usability of the magic angle spinning NMR data. New developments for solution NMR analysis include high performance liquid chromatography, NMR, mass spectroscopy and flow NMR. NMR-based methods currently being investigated may prove valuable as compound screening tools.
ISSN:1367-5931
1879-0402
DOI:10.1016/S1367-5931(98)80011-2