XANTHOCILLIN X MONOMETHYL ETHER, A POTENT INHIBITOR OF PROSTAGLANDIN BIOSYNTHESIS

Xanthocillin X monomethyl ether, known as an antiviral antibiotic, was isolated as a potent inhibitor of ichotomomyces cejpii. The compound inhibited prostaglandin synthesis from 14C-arachidonic acid in rabbit kidney microsomes by 50% at a concentration of 0.2 μM, while prostaglandin synthesis by mi...

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Bibliographic Details
Published in:Journal of antibiotics 1981, Vol.34(12), pp.1556-1561
Main Authors: KITAHARA, NOBUAKI, ENDO, AKIRA
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Butadienes - pharmacology
In Vitro Techniques
Indomethacin - pharmacology
Male
Prostaglandin Antagonists - pharmacology
Prostaglandins - biosynthesis
Rabbits
Rats
Rats, Inbred Strains
Sheep
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Summary:Xanthocillin X monomethyl ether, known as an antiviral antibiotic, was isolated as a potent inhibitor of ichotomomyces cejpii. The compound inhibited prostaglandin synthesis from 14C-arachidonic acid in rabbit kidney microsomes by 50% at a concentration of 0.2 μM, while prostaglandin synthesis by microsomes of ram seminal vesicle was inhibited by 50% at 20 μM. The inhibition by xanthocillin X monomethyl ether was reversible. Of the enzymatic steps involved in the synthesis of prostaglandins and thromboxanes tested, conversion of arachidonic acid into prostaglandin H2 was specifically inhibited by xanthocillin X monomethyl ether. Anti-inflammatory activity of this antibiotic on carrageenan-induced oedema in the rat foot was, however, not detectable.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.34.1556