Mutation in the α-synuclein gene and sporadic Parkinson's disease, alzheimer's disease, and dementia with Lewy bodies

Recently, alpha-synuclein attracted attention when Polymeropoulos and colleagues identified a missense mutation of this gene (Science 276:2045-2047, 1997), which is responsible for a form of early-onset familial Parkinson's disease (PD). Immunohistochemically, alpha-synuclein is localized in Le...

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Published in:Experimental neurology 1998-09, Vol.153 (1), p.164-166
Main Authors: HIGUCHI, S, ARAI, H, MATSUSHITA, S, MATSUI, T, KIMPARA, T, TAKEDA, A, SHIRAKURA, K
Format: Article
Language:English
Subjects:
Aged
alpha-Synuclein
Alzheimer Disease - genetics
Alzheimer Disease - metabolism
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia - genetics
Dementia - metabolism
DNA - biosynthesis
DNA - genetics
Genotype
Humans
Lewy Bodies - genetics
Lewy Bodies - metabolism
Medical sciences
Middle Aged
Mutation - genetics
Nerve Tissue Proteins - genetics
Neurology
Parkinson Disease - genetics
Parkinson Disease - metabolism
Phosphoproteins - genetics
Synucleins
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Summary:Recently, alpha-synuclein attracted attention when Polymeropoulos and colleagues identified a missense mutation of this gene (Science 276:2045-2047, 1997), which is responsible for a form of early-onset familial Parkinson's disease (PD). Immunohistochemically, alpha-synuclein is localized in Lewy bodies, characteristic brain pathology of PD, dementia with Lewy bodies (DLB), and Alzheimer's disease (AD), suggesting that this protein may link these common neurological diseases. Exploration of the possibility that the same mutation of the alpha-synuclein gene as that in familial PD (Ala53Thr) may also confer susceptibility to sporadic PD, DLB, and AD revealed the mutation in none of the samples of 329 cases and 230 controls examined, suggesting that this mutation is not involved in these neurological diseases.
ISSN:0014-4886
1090-2430
DOI:10.1006/exnr.1998.6868