The fate of competing beneficial mutations in an asexual population

In sexual populations, beneficial mutations that occur in different lineages may be recombined into a single lineage. In asexual populations, however, clones that carry such alternative beneficial mutations compete with one another and, thereby, interfere with the expected progression of a given mut...

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Bibliographic Details
Published in:Genetica 1998-01, Vol.102-103 (1-6), p.127-144
Main Authors: Gerrish, P J, Lenski, R E
Format: Article
Language:English
Subjects:
Bacteria
Computer Simulation
E coli
Escherichia coli - genetics
Gene Frequency
Models, Genetic
Models, Statistical
Mutation
Polymorphism, Genetic
Probability
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Summary:In sexual populations, beneficial mutations that occur in different lineages may be recombined into a single lineage. In asexual populations, however, clones that carry such alternative beneficial mutations compete with one another and, thereby, interfere with the expected progression of a given mutation to fixation. From theoretical exploration of such 'clonal interference', we have derived (1) a fixation probability for beneficial mutations, (2) an expected substitution rate, (3) an expected coefficient of selection for realized substitutions, (4) an expected rate of fitness increase, (5) the probability that a beneficial mutation transiently achieves polymorphic frequency (> or = 1%), and (6) the probability that a beneficial mutation transiently achieves majority status. Based on (2) and (3), we were able to estimate the beneficial mutation rate and the distribution of mutational effects from changes in mean fitness in an evolving E. coli population.
ISSN:0016-6707
1573-6857
DOI:10.1023/a:1017067816551